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Effect of prenatal ethanol exposure on sexual motivation in adult rats

机译：产前乙醇暴露对成年大鼠性动机的影响

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Maternal alcohol use during pregnancy adversely affects prenatal and postnatal growth and increases the risk of behavioral deficits. The aim of the present study was to evaluate the effect of prenatal exposure to a moderate dose of alcohol on sexual motivation during adulthood. Rats were prenatally exposed to ethanol by feeding pregnant dams a liquid diet containing 25% ethanol-derived calories on days 6 through 19 of gestation. The controls consisted of pair-fed dams (receiving an isocaloric liquid diet containing 0% ethanol-derived calories) and dams with ad libitum access to a liquid control diet. The sexual motivation of offspring was evaluated during adulthood. The results revealed that the male and female pups of dams treated with alcohol exhibited reduced weight gain, which persisted until adulthood. Both male and female adult animals from dams that were exposed to alcohol showed a reduction in the preference score in the sexual motivation test. Taken together, these results provide evidence of the damaging effects of prenatal alcohol exposure on sexual motivation responses in adulthood. (C) 2016 Elsevier Inc. All rights reserved.
机译：妊娠期间的产妇酒精使用对产前和产后生长产生不利影响，并提高行为赤字的风险。本研究的目的是评估产前暴露于成年期间性动机的中等剂量的饮酒。通过在妊娠期6至19天含有25％乙醇衍生的卡路里的液体饮食来预先暴露于乙醇的大鼠。该对照包括对喂养的坝（接受含有0％乙醇衍生的卡路里的异马洛液体饮食）和具有广告利用的水坝对液体控制饮食。在成年期间评估了后代的性动机。结果表明，用酒精治疗的坝的雄性和雌性幼崽表现出减轻重量增益，持续直至成年。来自暴露于酒精的坝的男性和女性成年动物都显示出性动机试验中偏好得分的减少。总之，这些结果提供了产前酒精暴露对成年性激励反应的破坏性作用的证据。 （c）2016年Elsevier Inc.保留所有权利。

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