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首页> 外文期刊>Alcohol >Did you drink alcohol during pregnancy? Inaccuracy and discontinuity of women's self-reports: On the way to establish meconium ethyl glucuronide (EtG) as a biomarker for alcohol consumption during pregnancy
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Did you drink alcohol during pregnancy? Inaccuracy and discontinuity of women's self-reports: On the way to establish meconium ethyl glucuronide (EtG) as a biomarker for alcohol consumption during pregnancy

机译：怀孕期间喝酒了吗？ 妇女自我报告的不准确性和不连续性：在建立甲氧基葡萄糖醛酸（ETG）作为妊娠期间饮酒的生物标志物的方式

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摘要

Consuming alcohol during pregnancy is one of the most verified prenatal risk factors for impaired child development. Information about the amount of alcohol consumed prenatally is needed to anticipate negative effects and to offer timely support. Women's self-reports are not reliable, often influenced by social stigmas and retrospective recall bias, causing biomarkers of intrauterine ethanol exposure to become more and more relevant. The present study compares both women's gestational and retrospective self-reports of prenatal alcohol consumption with levels of ethyl glucuronide (EtG) in meconium. Women (n = 180) gave self-reports of prenatal alcohol consumption both during their 3rd trimester (gestational self-report) and when their children were 6-8 years old (retrospective self-report). Child meconium was collected after birth and analyzed for EtG. No individual feedback of children's EtG level was given to the women. All analyses were run separately for two cut-offs: 10 ng/g (limit of detection) and 120 ng/g (established by Goecke et al., 2014). Mothers of children with EtG values above 10 ng/g (n = 42) tended to report prenatal alcohol consumption more frequently. There was no trend or significance for the EtG cut-off of 120 ng/g (n = 26) or for retrospective self-report. When focusing on women who retrospectively reported alcohol consumption during pregnancy, a claim to five or more consumed glasses per month made an EtG over the 10 ng/g and the 120 ng/g cut-off more probable. Women whose children were over the 10 ng/g EtG cut-off were the most inconsistent in their self-report behavior, whereas the consistency in the above 120 ng/g EtG group was higher than in any other group. The next step to establish EtG as a biomarker for intrauterine alcohol exposure is to correlate EtG values in meconium with child developmental impairments. (C) 2016 Elsevier Inc. All rights reserved.
机译：怀孕期间饮酒是儿童发展受损最严重的产前危险因素之一。需要预测负面影响并及时支持所需的酒精量的信息。妇女的自我报告不可靠，往往受到社会柱头和回顾性召回偏差的影响，导致宫内乙醇的生物标志物暴露，变得越来越相关。本研究将女性的妊娠和回顾性自我报告与产前醇消费的妊娠和回顾自我报告与MeConium中的乙基葡糖醛（ETG）水平进行了孕产量。女性（n = 180）在第3个三个月（妊娠自我报告）和6-8岁（回顾自我报告）中，给予了自我报告的产前酒精消费。儿童粉末在出生后收集并分析ETG。没有对妇女提供儿童ETG水平的个人反馈。所有分析都分别运行，两个截止值：10 ng / g（检测限）和120 ng / g（由Goecke等，2014年建立）。在10 ng / g（n = 42）以上的ETG值的母亲倾向于更频繁地报告产前酒精消费。对于120 ng / g（n = 26）或回顾性自我报告没有趋势或显着性。当专注于怀孕期间回顾性饮酒的妇女时，每月的五种或更多种消耗的玻璃，在10ng / g上产生ETG，120ng / g切断更可能。儿童超过10 ng / g eTG截止的女性是自我报告行为中最不一致的，而上述120 ng / g ETG组的一致性高于任何其他组。将ETG作为宫内酒精暴露的生物标志物建立ETG的下一步是在具有儿童发育障碍中将ETG值与子发育障碍相关联。 （c）2016年Elsevier Inc.保留所有权利。

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  • 来源
    《Alcohol》 |2016年第2016期|共6页
  • 作者

    Eichler Anna; Grunitz Juliane; Grimm Jennifer; Walz Lisa; Raabe Eva; Goecke Tamme W.; Beckmann Matthias W.; Kratz Oliver; Heinrich Hartmut; Moll Gunther H.; Fasching Peter A.; Kornhuber Johannes;

  • 作者单位

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Dept Obstet &

    Gynecol Univ Str 21-23 D-91054 Erlangen;

    Univ Erlangen Nurnberg Univ Hosp Erlangen Dept Obstet &

    Gynecol Univ Str 21-23 D-91054 Erlangen;

    Univ Erlangen Nurnberg Univ Hosp Erlangen Dept Obstet &

    Gynecol Univ Str 21-23 D-91054 Erlangen;

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Div Child &

    Adolescent Mental Hlth Schwabachanlage 6 &

    Univ Erlangen Nurnberg Univ Hosp Erlangen Dept Obstet &

    Gynecol Univ Str 21-23 D-91054 Erlangen;

    Univ Erlangen Nurnberg Univ Hosp Erlangen Dept Psychiat &

    Psychotherapy Schwabachanlage 6 D;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

    Alcohol; Pregnancy; Self-report; Meconium; Ethyl glucuronide; EtG;

    机译：酒精;怀孕;自我报告;粉末;乙基葡糖醛酸乙酯;ETG;

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