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Impaired homocysteine metabolism in patients with alcoholic liver disease in Taiwan

机译：台湾酒精性肝病患者的同型半胱氨酸代谢受损

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Impaired homocysteine metabolism plays an important role in alcoholic liver disease (ALD); however, there are limited data about its relationship with the risk and severity of patients with ALD in Taiwan. To understand plasma homocysteine and related vitamin concentrations in patients with ALD in Taiwan, we recruited 50 male patients with ALD from Cathay General Hospital, with 49 age-and gender-matched healthy adults as the control group. The Institutional Review Board for Human Studies approved the study, and informed consent was obtained from all patients prior to blood collection. Significantly higher plasma homocysteine concentrations but lower folate concentrations were obtained from patients with ALD. In addition, patients with ALD showed a significant lower erythrocyte reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio but higher plasma thiobarbituric acid-reactive substance (TBARS) concentration, which indicated that oxidative stress was occurring in patients with ALD. A negative correlation between plasma folate and homocysteine was observed in all subjects. There was also a negative correlation between plasma homocysteine and the erythrocyte GSH/GSSG ratio which indicated impaired homocysteine metabolism may have disrupted the antioxidative status. In addition, patients in Child-Pugh Class B and C showed higher plasma vitamin B-12 concentrations than did patients without cirrhosis and patients in Child-Pugh Class A. These findings show that impaired homocysteine metabolism was observed in patients with ALD in Taiwan. In addition, the plasma vitamin B-12 concentration may reflect the degree of liver injury. (C) 2016 Elsevier Inc. All rights reserved.
机译：患有障碍在酒精性肝病（ALD）中起重要作用。然而，关于其与台湾ALD患者的风险和严重程度的关系存在有限的数据。为了了解台湾ALD患者的血浆同型半胱氨酸和相关维生素浓度，我们招募了50名来自Cathay Arcecth医院的ALD患者，49名年龄和性别匹配的健康成年人作为对照组。人类研究的机构审查委员会批准了该研究，并从血液收集前的所有患者获得了知情同意。显着较高的血浆同型素浓度，但从ALD患者获得较低的叶酸浓度。此外，ALD的患者表现出显着的下红细胞减少的谷胱甘肽（GSH）/氧化谷胱甘肽（GSSG）的比例，但血浆硫氨基吡啶酸反应性物质（TBARS）浓度较高，表明氧化胁迫在ALD患者中发生氧化胁迫。在所有受试者中观察到血浆叶酸和同型半胱氨酸之间的负相关性。血浆同型半胱氨酸和红细胞GSH / GSSG比率之间也存在阴性相关性，其明显损害的同型半胱氨酸代谢可能破坏了抗氧化状态。此外，Child-Pugh B类和C的患者表现出比没有肝硬化和Child-Pugh级别的患者的血浆维生素B-12浓度比没有肝硬化和患者的患者。这些发现表明台湾ALD患者中观察到同型半胱氨酸代谢受损。此外，血浆维生素B-12浓度可能反映肝损伤程度。 （c）2016年Elsevier Inc.保留所有权利。

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