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首页> 外文期刊>Alcohol >Adolescent intake of caffeinated energy drinks does not affect adult alcohol consumption in C57BL/6 and BALB/c mice
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Adolescent intake of caffeinated energy drinks does not affect adult alcohol consumption in C57BL/6 and BALB/c mice

机译：青少年摄入含咖啡因能量饮料不会影响C57BL / 6和BALB / C小鼠的成人醇消耗

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The rise in marketing and mass consumption of energy drink products by adolescents poses a largely unknown risk on adolescent development and drug reward. Yet, with increasing reports of acute health issues present in young adults who ingest large quantities of energy drinks alone or in combination with alcohol, the need to elucidate these potential risks is pressing. Energy drinks contain high levels of caffeine and sucrose; therefore, exposure to energy drinks may lead to changes in drug-related behaviors since caffeine and sucrose consumption activates similar brain pathways engaged by substances of abuse. With a recent study observing that adolescent caffeine consumption increased cocaine sensitivity, we sought to investigate how prolonged energy drink exposure in adolescence alters alcohol use and preference in adulthood. To do so, we utilized three different energy drink exposure paradigms and two strains of male mice (C57BL/6 and BALB/c) to monitor the effect of caffeine exposure via energy drinks in adolescence on adult alcohol intake. These paradigms included two models of volitional consumption of energy drinks or energy drink-like substances and one model of forced consumption of sucrose solutions with different caffeine concentrations. Following adolescent exposure to these solutions, alcohol intake was monitored in a limited-access, two-bottle choice between water and increasing concentrations of alcohol during adulthood. In none of the three models or two strains of mice did we observe that adolescent 'energy drink' consumption or exposure was correlated with changes in adult alcohol intake or preference. While our current preclinical results suggest that exposure to large amounts of caffeine does not alter future alcohol intake, differences in caffeine metabolism between mice and humans need to be considered before translating these results to humans. (C) 2016 Elsevier Inc. All rights reserved.
机译：青少年营销和群众的营销和大规模消费量的兴起对青少年发展和药物奖励的影响很大。然而，随着越来越多的年轻成年人存在的急性健康问题的报告，他们独自摄取大量能量饮料或与酒精组合，需要阐明这些潜在风险的必要性是压制的。能量饮料含有高水平的咖啡因和蔗糖;因此，由于咖啡因和蔗糖消耗使能量饮料的暴露可能导致药物相关行为的变化激活由滥用物质接合的类似脑途径。随着最近的研究观察，青春期咖啡因消耗增加了可卡因敏感性，我们试图调查青春期的延长能量饮料暴露在成年期内的酒精使用和偏好。为此，我们使用了三种不同的能量饮料暴露范例和两种雄性小鼠（C57BL / 6和BALB / C），以通过青春期的能量饮料对白细胞饮料进行咖啡因暴露的影响。这些范式包括两种类似能量饮料或能量饮料物质的模型，以及具有不同咖啡因浓度的蔗糖溶液的强制消耗模型。在对这些解决方案的青少年接触后，在有限公司的有限公司之间监测酒精摄入量，在过去的水中和增加的成年期间醇浓度增加。在三种模型或两种小鼠中没有任何一部分，我们观察到青少年的“能量饮料”消费或暴露与成人酒精摄入或偏好的变化相关。虽然我们目前的临床前结果表明，暴露于大量的咖啡因不会改变未来的酒精摄入量，但在将这些结果转化为人类之前，需要考虑小鼠和人类之间的咖啡因代谢的差异。 （c）2016年Elsevier Inc.保留所有权利。

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