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Association of testosterone and BDNF serum levels with craving during alcohol withdrawal

机译：睾酮和BDNF血清水平与渴望期间的睾酮和BDNF血清水平

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摘要

Preclinical and clinical studies show associations between testosterone and brain-derived neurotrophic growth factor (BDNF) serum levels. BDNF and testosterone have been independently reported to influence alcohol consumption. Therefore, we aimed to investigate a possible interplay of testosterone and BDNF contributing to alcohol dependence. Regarding possible interplay of testosterone and BDNF and the activity of the hypothalamic pituitary axis (HPA), we included cortisol serum levels in our research. We investigated testosterone and BDNF serum levels in a sample of 99 male alcohol-dependent patients during alcohol withdrawal (day 1, 7, and 14) and compared them to a healthy male control group (n = 17). The testosterone serum levels were significantly (p < 0.001) higher in the patients' group than in the control group and decreased significantly during alcohol withdrawal (p < 0.001). The decrease of testosterone serum levels during alcohol withdrawal (days 1-7) was significantly associated with the BDNF serum levels (day 1: p = 0.008). In a subgroup of patients showing high cortisol serum levels (putatively mirroring high HPA activity), we found a significant association of BDNF and testosterone as well as with alcohol craving measured by the Obsessive and Compulsive Drinking Scale (OCDS). Our data suggest a possible association of BDNF and testosterone serum levels, which may be relevant for the symptomatology of alcohol dependence. Further studies are needed to clarify our results. (C) 2016 Elsevier Inc. All rights reserved.
机译：临床前与临床研究表明睾酮和脑源性神经营养生长因子（BDNF）血清水平之间的关联。 BDNF和睾酮已经独立据报道，以影响醇消耗。因此，我们旨在探讨睾酮和BDNF的可能相互作用，有助于酒精依赖。关于睾酮和BDNF的可能相互作用以及下丘脑垂体轴（HPA）的活性，我们在我们的研究中包括皮质醇血清水平。在酒精戒断（第1,7和14天）期间，我们研究了睾酮和BDNF血清水平，并将其与健康的男性对照组（N = 17）进行比较。患者组中睾酮血清水平显着（p <0.001），比对照组更高，并且在饮酒期间减少（P <0.001）。醇戒毒期间睾酮血清水平的降低与BDNF血清水平显着相关（第1天：P = 0.008）。在显示高皮质醇血清水平的患者的亚组中（推测高HPA活性），我们发现了BDNF和睾酮的重要关联，以及由强迫饮酒量（OCDS）测量的酒精渴望。我们的数据表明BDNF和睾酮血清水平的可能性，这可能与酒精依赖的症状有关。需要进一步研究来澄清我们的结果。 （c）2016年Elsevier Inc.保留所有权利。

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  • 来源
    《Alcohol》 |2016年第2016期|共6页
  • 作者

    Heberlein Annemarie; Lenz Bernd; Opfermann Birgitt; Groschl Michael; Janke Eva; Stange Katrin; Groh Adrian; Kornhuber Johannes; Frieling Helge; Bleich Stefan; Hillemacher Thomas;

  • 作者单位

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Univ Erlangen Nurnberg Dept Psychiat &

    Psychotherapy Erlangen Germany;

    Med Dienst Krankenversicherungen Niedersachsen Hildesheimer Str 265-267 D-30519 Hannover Germany;

    Celer Switzerland AG Bioanalyt Lab Allmendstr 32 CH-8320 Fehraltorf Switzerland;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Univ Erlangen Nurnberg Dept Psychiat &

    Psychotherapy Erlangen Germany;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

    Hannover Med Sch Dept Psychiat Social Psychiat &

    Psychotherapy Ctr Addict Res CARe Carl Neuberg;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

    Testosterone; Alcohol withdrawal; Alcohol dependence; BDNF; Abstinence;

    机译：睾酮;酒精戒烟;酒精依赖;BDNF;禁欲;

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