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The effects of repeated forced ethanol consumption during adolescence on reproductive behaviors in male rats

机译：青春期反复乙醇消耗对雄性大鼠生殖行为的影响

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Adolescence is a sensitive period of brain development when changes in hormone levels may have long-lasting effects on synaptic connections and behavior. In humans, alcohol consumption frequently begins during this critical period, although the impact of early exposure has not been fully examined. The current study was designed to investigate short- and long-term effects of repeated forced ethanol consumption during adolescence on emerging reproductive behaviors. Twenty-six young male Long Evans rats were assigned to ethanol (Young EtOH, n = 12) or water (Young Control, n = 14) groups at postnatal day (P) 32, receiving a modified binge protocol of 3 g/kg of solution via gavage twice per week from P32 to P80. For comparison, another cohort of rats received a similar treatment paradigm in adulthood from P75-P133 (Adult EtOH, n = 8; Adult Control, n = 10). Reproductive behavior was assessed with tests for copulation, partner preference, and 50-kHz vocalizations during forced consumption (intoxication) and again after a 4-5 week period of abstinence. During forced consumption, the Young EtOH group showed significantly longer latencies on copulation tests than Young Controls, but these differences did not persist after abstinence. Different patterns were observed in Adult animals, who only showed significant, delayed impairments in the post-ejaculatory interval. Preference for sexually receptive females increased with sexual experience in both adolescent and adult rats, regardless of treatment during the forced consumption phase. However, after abstinence, the Young EtOH group showed a significantly reduced partner preference compared to the Young Control group, which may indicate long-term effects on sexual motivation. Additionally, during forced consumption the Young EtOH group tended to emit fewer ultrasonic vocalizations, perhaps reflecting impairments in sexual communication. Adult groups showed no differences in partner preference or vocalization tests at any time. Taken together, these findings indicate that repeated, intermittent ethanol exposure may have moderate effects on reproductive behavior that vary as a function of age. After abstinence, differences were only observed in the younger group, suggesting that the adolescent brain and behavior are more sensitive to ethanol exposure than the adult brain for sexual motivation and performance. (C) 2016 Elsevier Inc. All rights reserved.
机译：当激素水平的变化可能对突触连接和行为影响持久影响时，青春期是大脑发育的敏感期。在人类中，饮酒经常在这个关键时期开始始于，尽管早期暴露的影响尚未完全检查。目前的研究旨在探讨在青春期期间对新兴生殖行为的反复强制乙醇消费的短期和长期影响。在产后期（P）32的乙醇（幼体EtOH，N = 12）或水（幼肠，N = 14）组中分配了二十六只年轻男性长埃文斯大鼠，接受3g / kg的改性围口方案通过P32至P80每周通过Gavage溶液。为了比较，另一种大鼠队列在P75-P133（成人EtOH，N = 8中的成年族群中获得了类似的治疗范式。在强制消费期间和50-kHz发声的测试中评估了生殖行为，并在禁欲4-5周后再次进行了一次。在强制消耗期间，年轻的EtOH集团比年轻对照表现出的交联测试显着更长，但在禁欲之后这些差异并没有持续存在。在成年动物中观察到不同的模式，该动物仅在后射精间隔内显示出显着延迟延迟损伤。无论在强制消费阶段治疗，偏爱性接受女性的偏好随着青少年和成人大鼠的性经验而增加。然而，在禁欲之后，与年轻对照组相比，年轻的EtOH集团表现出显着减少的伴侣偏好，这可能表明对性动机的长期影响。此外，在强制消耗期间，年轻ETOH集团倾向于发出更少的超声波发声，也许反映了性交流的障碍。成人组在任何时候都没有伴随合作伙伴偏好或发声测试的差异。在一起，这些发现表明，重复的间歇性乙醇暴露可能对繁殖行为具有中等的影响，这些行为变得随年龄的函数而变化。在禁欲之后，患者在较年轻的群体中仅观察到差异，表明青春期大脑和行为对乙醇暴露比成年人为性动机和性能更敏感。 （c）2016年Elsevier Inc.保留所有权利。

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