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Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use

机译：血清素转运蛋白基因的影响，对酒精的响应敏感性，以及患者饮酒风险的父母监测

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The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) has been previously associated with alcohol-related risk. Most findings point to short (S) allele carriers being at increased risk for negative alcohol outcomes relative to long allele homozygotes, although some work indicates a more complex relationship. The current prospective study aimed to clarify how and under what circumstances variations in 5-HTTLPR transmit risk for various alcohol-related outcomes. Participants were 218 adolescents and young adults (29% female) enrolled in the Michigan Longitudinal Study. We tested a moderated mediation model with 5-HTTLPR as the predictor, Self-Rating of the Effects of Alcohol (SRE) score as the mediator, alcohol-related outcomes as the dependent variables, parental monitoring as the moderator of the SRE to alcohol outcomes path, and prior drinks, sex, age, and body mass index as covariates. Four alcohol-related outcomes were tested. The S allele was associated with higher SRE scores (i.e., lower response to alcohol). Parental monitoring was a significant moderator: At low levels of parental monitoring, higher SRE scores predicted more drinks consumed and binge drinking episodes. At high levels of monitoring, higher SRE scores were significantly related to fewer alcohol-related problems. Findings suggest that one mechanism by which 5-HTTLPR variation transmits alcohol-related risk is through level of response to alcohol. Furthermore, the strength and direction of this effect varied by level of parental monitoring, indicating that even in the presence of genetic and physiological vulnerability, parents can influence the likelihood of offspring developing problematic alcohol-related behaviors. (C) 2016 The Authors. Published by Elsevier Inc.
机译：血清素转运蛋白转运蛋白转运蛋白转运蛋白基因（SLC6A4）的血清素转运蛋白连接多态性区域（5-HTTLPR）先前已与酒精相关的风险相关。大多数发现指向短暂的等位基因载体相对于长等位基因纯合子的阴性酒精结果的风险增加，尽管有些作品表明了更复杂的关系。目前的前瞻性研究旨在澄清如何以及根据各种饮酒相关结果的5-HTTLPR传输风险的变化。参与者是218名青少年和年轻人（29％女性）注册密歇根州纵向研究。我们用5-httlpr测试了一个适度的中介模型作为预测因子，酒精（sre）评分的自我评级为介质，酒精相关的结果作为依赖变量，父母监测作为sre的主持人，以饮酒结果道路，以及前饮料，性别，年龄和体重指数作为协变量。测试了四种与酗酒的结果进行了测试。 S等位基因与较高的SRE分数（即对酒精的响应较低）有关。父母监测是一个重要的主持人：在低水平的父母监测中，较高的SRE评分预测了更多的饮料消耗和狂暴饮食集。在高水平的监测下，较高的SRE分数与更少的酒精相关问题显着相关。调查结果表明，5-HTTLPR变异传递酒精相关风险的一种机制是通过对酒精的反应水平。此外，这种效果的强度和方向因亲本监测水平而变化，表明即使在存在遗传和生理漏洞中，父母也可以影响后代发育有问题的酒精相关行为的可能性。 （c）2016年作者。 elsevier公司发布

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