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首页> 外文期刊>Alcohol >Chronic moderate alcohol drinking alters insulin release without affecting cognitive and emotion-like behaviors in rats
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Chronic moderate alcohol drinking alters insulin release without affecting cognitive and emotion-like behaviors in rats

机译：慢性适度的酒精饮用改变胰岛素释放，而不会影响大鼠的认知和情绪样行为

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Because the consumption of alcoholic beverages prevails in society, its effects on diabetes risk is a subject of interest. Extant literature on this issue often disagrees. Here, we probed the effects of chronic moderate ethanol consumption on glucose metabolism in rats. The effect of chronic moderate alcohol drinking on depression- and anxiety-like behaviors and memory was also explored. Adolescent male and female Long-Evans rats consumed saccharin-sweetened 5% (1 week) and 10% ethanol (7 weeks) under a 7.5-h/day (Monday–Friday) access schedule. This exposure was followed by sucrose preference and elevated plus maze (EPM) tests during an intervening week, before a 6-week intermittent-access (Monday, Wednesday, Friday) to 20% unsweetened ethanol in a 2-bottle choice drinking paradigm was implemented (EtOH). A free-feeding control group received water (Water). Our prior work revealed that voluntary ethanol consumption decreases food intake in rats. Hence, a second control group that received water was mildly food-restricted (FR), and their average body weight was matched to that of the EtOH group. During the week following week 6 of intermittent-access to 20% ethanol, rats were submitted to sucrose preference, EPM, and novel object recognition (NOR) tests. Insulin response to a glucose load was subsequently assessed via an oral glucose tolerance test (OGTT). Rats attained and maintained blood ethanol concentrations of ～55?mg/dL that correlated with the dose of sweetened 10% ethanol ingested. Relative to intake by Water controls, EtOH rats consumed less chow. There was no body weight difference between both groups. Neither sex of EtOH rats showed increased depression- and anxiety-like behaviors, as respectively measured by sucrose preference and EPM, nor did they show deficit in object recognition memory during abstinence. Male EtOH rats, however, showed signs of reduced general activity on the EPM. During OGTT, male EtOH rats showed a time-dependent potentiation of insulin release for proper glucose clearance. Such an effect was not observed in females. This landmark study shows that chronic moderate alcohol consumption can have negative metabolic consequences in the absence of overt behavioral deficits, especially in males.
机译：由于社会中含酒精饮料的消费普遍存在，因此其对糖尿病风险的影响是一个兴趣的主题。在这个问题上的现存文学往往不同意。在这里，我们探讨了慢性中度乙醇消耗对大鼠葡萄糖代谢的影响。还探讨了慢性温和酒精饮用对抑郁和焦虑的行为和记忆的影响。青春期男性和女性长evans大鼠在7.5小时/天（星期一星期五）访问时间表中消耗糖精5％（1周）和10％乙醇（7周）。这种暴露在蔗糖偏好和升高的加迷宫（EPM）测试中，在一个介入的一周内，在一个6周间歇式（星期一，星期三，星期五）到20％不含香膜选择的乙醇中实施了2瓶选择饮用范式。 （Etoh）。自由喂养对照组接收水（水）。我们的上班前透露，自愿乙醇消费减少了大鼠的食物摄入量。因此，接受水的第二对照组是温和的食物限制（FR），并且它们的平均体重与EtOH基团的平均体重匹配。在间歇式接入20％乙醇的第6周期间，大鼠提交给蔗糖偏好，EPM和新的对象识别（也不）测试。随后通过口服葡萄糖耐量试验（OGTT）评估对葡萄糖负荷的胰岛素反应。大鼠达到并维持血液乙醇浓度为约55μg/ d1，其与摄取的10％乙醇的剂量相关。相对于水对照的摄入量，EtOH大鼠消耗较少的咸味。两组之间没有体重差异。牙龈大鼠的性别既不显示出抑郁症和焦虑的行为增加，分别通过蔗糖偏好和EPM测量，也没有显示在禁欲期间对象识别记忆中的缺陷。然而，雄性EtOH大鼠显示了对EPM上的一般活动的迹象。在OGTT期间，雄性EtOH大鼠表现出胰岛素释放的时间依赖性增强，以进行适当的葡萄糖间隙。女性未观察到这种效果。这种地标研究表明，慢性中度酒精消费可以在没有公开的行为缺陷的情况下具有负面代谢后果，特别是在雄性中。

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