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首页> 外文期刊>Alcohol >Predator-based psychosocial stress model of PTSD differentially influences voluntary ethanol consumption depending on methodology
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Predator-based psychosocial stress model of PTSD differentially influences voluntary ethanol consumption depending on methodology

机译：PTSD的捕食者对心理社会应激模型差异影响自愿乙醇消费取决于方法论

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Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder typified by diagnostic symptom clusters including hyperarousal, avoidance, negative cognitions and mood, and intrusive re-experiencing of the traumatic event. Patients with PTSD have been reported to self-medicate with alcohol to ameliorate hyperarousal symptoms associated with the disorder. Research utilizing rodent models of PTSD to emulate this behavioral phenomenon has thus far yielded inconsistent results. In the present study, we examined the effects of a predator-based psychosocial stress model of PTSD on voluntary ethanol consumption. In the first of two experiments, following exposure to a 31-day stress or control paradigm, rats were singly housed during the dark cycle with free access to 1% sucrose solution or 10% ethanol, which was also sweetened with 1% sucrose. Over the course of a 20-day period of ethanol access, stressed rats consumed significantly less ethanol than non-stressed rats. These counterintuitive results prompted the completion of a second experiment which was identical to the first, except rats were also exposed to the two-bottle paradigm for 20 days before the stress or control paradigm. In the second experiment, after the stress manipulation, stressed rats exhibited significantly greater ethanol preference than non-stressed rats. These findings suggest that prior exposure to ethanol influences the subsequent effect of stress on ethanol intake. They also validate the use of the present model of PTSD to examine potential mechanisms underlying stress-related changes in ethanol-seeking behavior.
机译：创伤后应激障碍（PTSD）是一种衰弱的心理障碍，其诊断症状集群包括包括古静脉，避免，负认知和情绪，以及创伤事件的侵入性再次验收。据报道，患有PTSD的患者将饮酒与酒精一起用来改善与疾病相关的型静脉症状。利用PTSD啮齿动物模型的研究迄今为止，利用PTSD的啮齿动物模型产生了不一致的结果。在本研究中，我们研究了PTSD捕食性心理社会应激模型对自愿乙醇消费的影响。在两个实验中的第一个实验中，在暴露于31天的应激或对照范例之后，在黑暗循环期间单独容纳大鼠，并自由获得1％蔗糖溶液或10％乙醇，其也用1％蔗糖加糖。在乙醇接入的20天期的过程中，压力大鼠比非压力大鼠产生显着较少的乙醇。这些违反直接结果促使完成与第一实验相同的第二种实验，除了大鼠在压力或控制范例之前20天暴露于双瓶范式20天。在第二个实验中，在应力操作之后，应强调大鼠比非应激大鼠显示出明显更大的乙醇偏好。这些发现表明，在乙醇前之前暴露在乙醇摄入的后续影响。他们还验证了PTSD目前模型的使用，以检查潜在的潜在机制相关的乙醇寻求行为中的压力相关变化。

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