...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS >Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study
【24h】

Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study

机译：骨质损失与抗逆转录病毒 - 幼稚艾滋病毒感染的成年人有关的骨质损失与慢性炎症有关吗？ 一个48周的竞赛队列研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE:: Antiretroviral therapy (ART) has been implicated in bone loss in HIV. The role of inflammation and vitamin D is unclear and better investigated in ART-naive individuals. DESIGN AND METHODS:: This is a 48-week, prospective cohort study to compare baseline and change in hip and spine bone mineral density (BMD) measured by dual-energy X-ray absorptiometry in HIV-infected, ART-naive adults and healthy controls matched by age, sex, and race. We also studied associations between bone loss and inflammation markers and plasma 25-hydroxyvitamin D [25(OH)D] using logistic regression. RESULTS:: Forty-seven HIV-infected adults and 41 controls were included. Baseline 25(OH)D, BMD at total hip, trochanter, and spine, and prevalence of osteopenia and osteoporosis were similar between groups. In the HIV-infected group, total hip and trochanter, but not spine, BMD decreased over 48 weeks [hip-0.005 (-0.026-0.008) g/cm, P=0.02 within group; trochanter-0.013 (-0.03-0.003), P<0.01]. BMD did not change at any site within controls. The HIV-infected group was more likely to have bone loss at the trochanter (P=0.03). This risk persisted after adjustment for age, sex, race, BMI, smoking, and hepatitis C (odds ratio 4, 95% confidence interval 1.2-15.8). In the HIV-infected group, higher interleukin-6 concentrations (P=0.04) and Caucasian race (P<0.01) were independently associated with progression to osteopenia or osteoporosis, but not 25(OH)D levels. CONCLUSION:: BMD at the total hip and trochanter sites decreased in the HIV-infected, ART-naive adults, but not controls, over this 48-week study. Higher serum interleukin-6 concentrations were associated with progression to osteopenia or osteoporosis status in the HIV-infected group.
机译：目的::抗逆转录病毒治疗（ART）涉及艾滋病毒的骨质流失。炎症和维生素D的作用尚不清楚，在艺术幼稚的个体中更好地研究。设计和方法::这是一个48周，前瞻性队列研究，以比较艾滋病毒感染，艺术 - 幼稚成年人和健康的双能X射线吸收测定的髋关节和脊柱骨密度（BMD）的基线和脊柱骨密度（BMD）的变化按年龄，性和种族匹配的控制。我们还使用Logistic回归研究了骨质损失和炎症标记物和炎症标记物和血浆25-羟基vitamind [25（OH）D]的关联。结果:: 47名艾滋病毒感染的成年人和41个控制。基线25（OH）D，BMD在总髋髋，脱叶和脊柱上，骨质缺乏症的患病率和骨质疏松症之间相似。在艾滋病毒感染的群体中，总髋关节和脱叶，但不是脊柱，BMD在48周内减少[髋关节-005（-0.026-0.008）g / cm，p = 0.02; Trochanter-0.013（-0.03-0.003），P <0.01]。 BMD在控制中的任何站点都没有更改。艾滋病毒感染的群体更可能在Trochanter上具有骨质损失（P = 0.03）。调整年龄，性别，种族，BMI，吸烟和丙型肝炎（odds比率4,95％置信区间1.2-15.8）后，这种风险持续存在。在艾滋病毒感染的群体中，更高的白种介素-6浓度（P = 0.04）和白种人种族（P <0.01）与骨质增长或骨质疏松症的进展单独相关，但不是25（OH）D水平。结论:: BMD在艾滋病毒感染，艺术 - 天真的成年人中，艾滋病毒感染，艺术 - 幼稚成年人的总髋关节和转子部位下降，但在这项48周的研究中没有控制。较高的血清白细胞介素-6浓度与艾滋病毒感染群体中的骨质增长或骨质疏松状态的进展相关。

著录项

  • 来源
    《AIDS》 |2014年第12期|共9页
  • 作者

    HilemanC.O.; LabbatoD.E.; StorerN.J.; TangprichaV.; McComseyG.A.;

  • 作者单位

    Case Western Reserve University School of Medicine Department of Pediatrics and Medicine 11100;

    Case Western Reserve University School of Medicine Department of Pediatrics and Medicine 11100;

    Case Western Reserve University School of Medicine Department of Pediatrics and Medicine 11100;

    Emory University School of Medicine Atlanta GA United States;

    Case Western Reserve University School of Medicine Department of Pediatrics and Medicine 11100;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    antiretroviral-na?ve; bone loss; bone mineral density; inflammation; vitamin D;

    机译：抗逆转录病毒-NA？ve;骨质损失;骨矿物密度;炎症;维生素D;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号