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首页> 外文期刊>AIDS >Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study
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Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study

机译：初次感染抗逆转录病毒的成年人的骨质流失是否与慢性炎症有关？一项为期48周的队列研究

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OBJECTIVE:: Antiretroviral therapy (ART) has been implicated in bone loss in HIV. The role of inflammation and vitamin D is unclear and better investigated in ART-naive individuals. DESIGN AND METHODS:: This is a 48-week, prospective cohort study to compare baseline and change in hip and spine bone mineral density (BMD) measured by dual-energy X-ray absorptiometry in HIV-infected, ART-naive adults and healthy controls matched by age, sex, and race. We also studied associations between bone loss and inflammation markers and plasma 25-hydroxyvitamin D [25(OH)D] using logistic regression. RESULTS:: Forty-seven HIV-infected adults and 41 controls were included. Baseline 25(OH)D, BMD at total hip, trochanter, and spine, and prevalence of osteopenia and osteoporosis were similar between groups. In the HIV-infected group, total hip and trochanter, but not spine, BMD decreased over 48 weeks [hip-0.005 (-0.026-0.008) g/cm, P=0.02 within group; trochanter-0.013 (-0.03-0.003), P<0.01]. BMD did not change at any site within controls. The HIV-infected group was more likely to have bone loss at the trochanter (P=0.03). This risk persisted after adjustment for age, sex, race, BMI, smoking, and hepatitis C (odds ratio 4, 95% confidence interval 1.2-15.8). In the HIV-infected group, higher interleukin-6 concentrations (P=0.04) and Caucasian race (P<0.01) were independently associated with progression to osteopenia or osteoporosis, but not 25(OH)D levels. CONCLUSION:: BMD at the total hip and trochanter sites decreased in the HIV-infected, ART-naive adults, but not controls, over this 48-week study. Higher serum interleukin-6 concentrations were associated with progression to osteopenia or osteoporosis status in the HIV-infected group.
机译：目的：抗逆转录病毒疗法（ART）与HIV的骨质流失有关。炎症和维生素D的作用尚不清楚，在未接受ART治疗的个体中进行了更好的研究。设计与方法：：这是一项为期48周的前瞻性队列研究，旨在比较在HIV感染，未接受ART治疗的成年人和健康人群中通过双能X射线吸收法测量的基线和髋部和脊柱骨矿物质密度（BMD）的变化根据年龄，性别和种族匹配的控件。我们还使用逻辑回归研究了骨丢失和炎症标志物与血浆25-羟基维生素D [25（OH）D]之间的关联。结果：包括47名HIV感染的成年人和41名对照。两组之间的基线25（OH）D，全髋，大转子和脊柱的BMD以及骨质减少和骨质疏松的患病率相似。在HIV感染组中，全髋关节和转子，而非脊柱，BMD在48周内下降[hip-0.005（-0.026-0.008）g / cm，组内P = 0.02;转子-0.013（-0.03-0.003），P <0.01]。 BMD在控件内的任何位置均未更改。感染艾滋病毒的人群更可能在转子上出现骨质流失（P = 0.03）。在调整了年龄，性别，种族，BMI，吸烟和丙型肝炎之后，这种风险仍然存在（赔率4，95％的置信区间1.2-15.8）。在HIV感染组中，较高的白介素6浓度（P = 0.04）和白种人（P <0.01）与骨质减少或骨质疏松的进展独立相关，但与25（OH）D水平无关。结论：在这项为期48周的研究中，HIV感染，未接受ART治疗的成年人的髋部和转子总部位的BMD降低了，但对照组没有降低。在HIV感染组中，较高的血清白介素6浓度与骨质减少或骨质疏松状态的进展有关。

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