Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability

Balinang Joyce M.; Masvekar Ruturaj R.; Hauser Kurt F.; Knapp Pamela E.

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Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability

机译：R5热带HIV-1的人类神经祖细胞的生产感染：Apiate共曝光高度感染性和功能脆弱性

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Objective: HIV type-1 (HIV-1) causes a spectrum of central nervous system (CNS) complications; many are worsened by opiate co-exposure. Human neural progenitor cells (hNPCs) give rise to all CNS neurons and macroglia. We tested the hypothesis that hNPC maturation and fate are altered by HIV and opiates, contributing to HIV-1-related neuropathology. Reports of hNPC infection remain controversial. We rigorously examined this question, testing whether hNPCs propogated infection, and whether HIV affected hNPCs absent their infection.

机译：目的：艾滋病毒型-1（HIV-1）导致中枢神经系统（CNS）并发症的光谱; 许多人因鸦片连通而恶化。人的神经祖细胞（HNPC）引起所有CNS神经元和宏观LIA。我们测试了HNPC成熟和命运的假设是通过HIV和Apiates改变的，有助于HIV-1相关神经病理学。报告HNPC感染仍然存在争议。我们严格检查了这个问题，测试了HNPCS漂]感染，以及艾滋病病毒是否受影响的HNPC缺乏感染。

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《AIDS》 |2017年第6期|共12页
作者
Balinang Joyce M.; Masvekar Ruturaj R.; Hauser Kurt F.; Knapp Pamela E.;
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作者单位

Virginia Commonwealth Univ Dept Anat &

Neurobiol Richmond VA USA;

Virginia Commonwealth Univ Dept Anat &

Neurobiol Richmond VA USA;

Virginia Commonwealth Univ Dept Anat &

Neurobiol Richmond VA USA;

Virginia Commonwealth Univ Dept Anat &

Neurobiol Richmond VA USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
CNS development; HIV-1-associated neurocognitive disorder; HIV-1 reservoir; morphine; neuroAIDS; drug abuse; perinatal; maraviroc;

机译：CNS开发;HIV-1相关神经认知障碍;HIV-1储层;吗啡;神经外德;药物滥用;围产期;Maraviroc;

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1. Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability [J] . Balinang Joyce M., Masvekar Ruturaj R., Hauser Kurt F., AIDS . 2017,第6期

机译：R5热带HIV-1的人类神经祖细胞的生产感染：Apiate共曝光高度感染性和功能脆弱性
2. Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes [J] . Paul J Peters, Maria Paz Gonzalez-Perez, Thomas Musich, Retrovirology . 2015,第S1期

机译：原发性非巨噬细胞型和高度巨噬细胞型HIV-1 R5包膜介导的子宫颈组织感染和T细胞的普遍靶向
3. Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro [J] . Vanessa A Evans, Luxshimi Lal, Ramesh Akkina, Retrovirology . 2011,第S1期

机译：胸腺浆细胞样树突状细胞易受生产性HIV-1感染，并在体外有效地将R5 HIV-1转移至胸腺细胞
4. Region-specific laminin-functionalized hydrogels for delivery of neural stem/progenitor cells [C] . D. Barros, J. Furtado, F. Ferreira-da-Silva, Society for Biomaterials annual meeting and exposition . 2017

机译：区域特异性层粘连蛋白功能化水凝胶用于神经干/祖细胞的递送
5. Human cytomegalovirus infection in human umbilical vein endothelial cells; human cytomegalovirus infection in hematopoietic progenitor cells: Model of HCMV latency [D] . Zhuravskya, Tatiana. 1997

机译：人脐静脉内皮细胞中的人巨细胞病毒感染；造血祖细胞中人类巨细胞病毒感染：HCMV潜伏期模型
6. Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability [O] . Joyce M. Balinang, Ruturaj R. Masvekar, Kurt F. Hauser, -1

机译：R5热带HIV-1对人神经祖细胞的生产性感染：阿片类药物共同暴露会提高感染力和功能脆弱性
7. Productive infection of human neural progenitor cells by R5 tropic HIV-1 [O] . Joyce M. Balinang, Ruturaj R. Masvekar, Kurt F. Hauser, 2017

机译：R5 Tropic HIV-1的人神经祖细胞的生产感染
8. 3D Normal Human Neural Progenitor Tissue-like Assemblies: A Model of Persistent Varicella Zoster Virus Infection and a Platform to Study Viral Infectivity and Oxidative Stress and Damage. [R] . Goodwin, T. J. 2014

机译：3D正常人类神经祖细胞组织样组件：持久性水痘带状疱疹病毒感染模型和研究病毒感染性和氧化应激和损伤的平台。

Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability

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