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首页> 外文期刊>Advances in anatomy embryology and cell biology. >Heat Shock Proteins and Maternal Contribution to Oogenesis and Early Embryogenesis
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Heat Shock Proteins and Maternal Contribution to Oogenesis and Early Embryogenesis

机译：热休克蛋白和母体对胚芽发生和早期胚胎发生的贡献

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摘要

Early embryos develop from fertilized eggs using materials that are stored during oocyte growth and which can be defined as maternal contribution (molecules, factors, or determinants). Several heat shock proteins (HSPs) and the heat shock transcriptional factor (HSF) are part of the maternal contribution that is critical for successful embryogenesis and reproduction. A maternal role for heat shock-related genes was mainly demonstrated in genetic experimental organisms (e.g., fly, nematode, mouse). Nowadays, an increasing number of "omics" data are produced from a large panel of organisms implementing a catalog of maternal and/or embryonic HSPs and HSFs. However, for most of them, it remains to better understand their potential roles in this context. Existing and future genome-wide screens mainly set up to create loss-of-function are likely to improve this situation. This chapter will discuss available data from various experimental organisms following the developmental steps from egg production to early embryogenesis.
机译：早期胚胎从卵母细胞生长期间储存的材料从受精卵中发育，并且可以定义为母体贡献（分子，因素或决定因素）。几种热休克蛋白（HSP）和热休克转录因子（HSF）是母体贡献的一部分，对于成功的胚胎发生和繁殖至关重要。在遗传实验生物（例如，飞行，线虫，小鼠）中主要证明了热冲击相关基因的母体作用。如今，越来越多的“OMIC”数据是由实现母体和/或胚胎HSP和HSF目录的大型组织组成的。但是，对于大多数人来说，它仍然更好地了解了这种背景下的潜在角色。现有和未来的基因组 - 范围屏幕主要建立造成努力损失可能会改善这种情况。本章将在从鸡蛋生产到早期胚胎发生的发育步骤后，从各种实验生物中讨论可用数据。

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