Chapter 4 The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies

Myriam Scherer; Eva-Maria Schilling; Thomas Stamminger

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Chapter 4 The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies

机译：第4章人体CMV IE1蛋白：PML核体的罪犯

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The mammalian immune system, which has evolved under continuous selective pressure of a wide range of microbes, is traditionally subclassified into two branches of innate and adaptive immunity. Only recently, intrinsic cellular-based defense mechanisms have been discovered as a third important branch of the immune defense. Intrinsic immunity is mediated by cellular restriction factors that are constitutively expressed and active even before a pathogen enters the cell. In contrast, classical innate immune mechanisms like the interferon response require pathogen-induced signaling cascades in order to be turned on.

机译：哺乳动物免疫系统，它在广泛的微生物的连续选择性压力下进化，传统上将其亚分类为先天和适应性免疫的两个分支。据最近，已发现基于内在的细胞的防御机制作为免疫防御的第三个重要分支。甚至在病原体进入细胞之前，内在免疫通过细胞限制因子介导的细胞限制因子。相反，像干扰素响应等古典先天的免疫机制需要病原体诱导的信号传导级联才能开启。

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《Advances in anatomy embryology and cell biology.》 |2017年第2017期|共18页
作者
Myriam Scherer; Eva-Maria Schilling; Thomas Stamminger;
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作者单位

Institute for Clinical and Molecular Virology Friedrich-Alexander-Universtitat (FAU) Erlangen;

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正文语种 eng
中图分类细胞生物学;
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1. Effect of HCMV IE1 Protein on Cytokines Secretion and Apoptosis of Macrophages [J] . CHEN Lin, WAN Yan-ping, CHAN Xi, 中国癌症研究（英文版） . 2008,第001期
2. Chapter 4 The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies [J] . Myriam Scherer, Eva-Maria Schilling, Thomas Stamminger Advances in anatomy embryology and cell biology. . 2017,第期

机译：第4章人体CMV IE1蛋白：PML核体的罪犯
3. N-terminal determinants of human cytomegalovirus IE1 protein in nuclear targeting and disrupting PML-associated subnuclear structures. [J] . Lee HR, Huh YH, Kim YE, Biochemical and Biophysical Research Communications . 2007,第2期

机译：核靶向核靶向人巨细胞病毒IE1蛋白的N-末端决定因素及破坏PML-相关亚核结构。
4. Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection. [J] . Ahn JH, Hayward GS Virology . 2000,第1期

机译：IE1对PML相关核的破坏与人巨细胞病毒感染中病毒基因表达和DNA复制的有效早期有关。
5. Silencing of Human Cytomegalovirus Gene Expression Mediated by Components of PML Nuclear Bodies [C] . Myriam Scherer, Nadine Wagenknecht, Nina Reuter, Weissenburg Symposium Biriciana . 2016

机译：PML核体组分介导的人巨细胞病毒基因表达的沉默
6. Chapter 1. Total synthesis of Fumonisin B1. Chapter 2. Synthesis of Unnatural Sphingolipids: 1-deoxy-5-hydroxysphinganine and its diastereomers. Chapter 3. Development of Methodology: Synthesis of cis- and trans-homoallylic alcohols. Chapter 4. Human Milk Oligosaccharides: Synthesis of Natural and Unnatural oligomers [D] . Pereira, Claney L. 2010

机译：第1章。伏马毒素B1的全合成。第二章。非天然鞘脂的合成：1-脱氧-5-羟基鞘氨醇及其非对映异构体。第3章方法的发展：顺式和反式均烯丙基醇的合成。第4章人乳寡糖：天然和非天然低聚物的合成
7. The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation [O] . Eva-Maria Schilling, Myriam Scherer, Nina Reuter, 2017

机译：人类巨细胞病毒IE1蛋白通过抑制PML De Novo SUMOylation拮抗PML核体介导的固有免疫。
8. Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML [O] . Ahn, Jin-Hyun, Brignole, Edward J., Hayward, Gary S. 1998

机译：人类巨细胞病毒的酸性IE1蛋白对PML亚核域的破坏是通过与PML相互作用介导的，并且可能调节PML的RING依赖于手指的隐性反式激活功能
9. In vitro Antigen-Specific Antibody Response to the Species-Specific Surface Protein Antigens of Typhus Group Rickettsiae by Human Peripheral Blood Mononuclear Cells. Generation of an Antigen-Dependent Suppressor T Cell [R] . Misiti, J., Dasch, G. A. 1985

机译：体外抗原特异性抗体对人外周血单个核细胞对斑疹伤寒组立克次体的物种特异性表面蛋白抗原的反应。产生抗原依赖性抑制T细胞

Chapter 4 The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies

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