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Chromatin Regulation of Early Embryonic Lineage Specification Introduction

机译：早期胚胎谱系规范的染色质调控介绍

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摘要

In this special volume on "Chromatin regulation of early embryonic lineage specification," five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
机译：在这种特殊体积上，“早期胚胎谱系统规范的染色素调节”，哺乳动物的胚胎胚胎发育领域的五个领导者在介导生命的第一周介导谱系形成的关键分子和细胞过程中提供了自己的视角。第一种细胞命运决策涉及形成多能内细胞质量（ICM）和ImroTembryonic逆分子（TE）。第二个细胞命运选择包括ICM转化为Interembryonic原始内胚层（PE）和多能外部的外部细胞。在预溶解发育期间发生的方法，作为随后的发育事件，例如植入，定位和腐殖液的基础。调节它们的机制是复杂的并且涉及许多不同因素在空间和时间上运行的不同因素在几天内进行调节，以调节胚胎染色质结构，施加细胞极性，以及在第一细胞谱系中的直接不同的基因表达程序。

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