Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials

Denson Aaron; Burke Nancy; Wapinsky Georgine; Bertels Barbara; Juan Tzu-Hua; Lee Jae; Springett Gregory M.; Strosberg Jonathan R.; Kim Richard D.; Sullivan Dan M.; Mahipal Amit

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Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials

机译：胃肠道恶性肿瘤患者的临床结果参与I期临床试验

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Objectives: Early-phase clinical trials play a pivotal role in drug development. However, limited data are available on outcomes of gastrointestinal (GI) cancer patients enrolled in phase I clinical trials. Here, we evaluated the characteristics associated with survival in GI cancer patients participating in phase I clinical trials and attempted to validate previously established prognostic models.

机译：目的：早期临床试验在药物开发中发挥关键作用。然而，有限的数据可以在I期临床试验中注册的胃肠道（GI）癌症患者的结果。在这里，我们评估了与参与I期临床试验的GI癌症患者的生存相关的特征，并试图验证以前建立的预后模型。

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来源
《American Journal of Clinical Oncology: Cancer Clinical Trials》 |2018年第2期|共7页
作者
Denson Aaron; Burke Nancy; Wapinsky Georgine; Bertels Barbara; Juan Tzu-Hua; Lee Jae; Springett Gregory M.; Strosberg Jonathan R.; Kim Richard D.; Sullivan Dan M.; Mahipal Amit;
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作者单位

Univ S Florida Dept Internal Med Tampa FL USA;

H Lee Moffitt Canc Ctr &

Res Inst Clin Res Unit Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Clin Res Unit Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Clin Res Unit Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Dept Biostat &

Bioinformat Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Dept Biostat &

Bioinformat Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Dept Gastrointestinal Oncol 12902 Magnolia Dr Tampa FL 33612;

H Lee Moffitt Canc Ctr &

Res Inst Dept Gastrointestinal Oncol 12902 Magnolia Dr Tampa FL 33612;

H Lee Moffitt Canc Ctr &

Res Inst Dept Gastrointestinal Oncol 12902 Magnolia Dr Tampa FL 33612;

H Lee Moffitt Canc Ctr &

Res Inst Chem Biol &

Mol Med Program Tampa FL 33612 USA;

H Lee Moffitt Canc Ctr &

Res Inst Dept Gastrointestinal Oncol 12902 Magnolia Dr Tampa FL 33612;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
clinical trial; phase I; gastrointestinal neoplasms; clinical trial; survival; therapeutics;

机译：临床试验;阶段I;胃肠肿瘤;临床试验;生存;治疗学;

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专利

1. Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials [J] . Denson Aaron, Burke Nancy, Wapinsky Georgine, American Journal of Clinical Oncology: Cancer Clinical Trials . 2018,第2期

机译：胃肠道恶性肿瘤患者的临床结果参与I期临床试验
2. Clinical outcome and prognostic markers for patients with gynecologic malignancies in phase 1 clinical trials: A single institution experience from 1999 to 2010 [J] . HouJ.Y., AparoS., GhalibM., Gynecologic Oncology: An International Journal . 2013,第1期

机译：妇科恶性肿瘤患者的1期临床试验的临床结局和预后指标：1999年至2010年的单一机构经验
3. Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials [J] . Yoshiaki Nagatani, Kohei Shitara, Hideaki Bando, BMC Cancer . 2016,第1期

机译：胃肠道间质瘤患者一期临床试验的临床结果
4. Patient in control in clinical trials - European initiatives for improving patient empowerment in clinical trials through technical implementation of legal norms [C] . Forgo Nikolaus, Goralczyk Magdalena, Hanold Stefanie Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：在临床试验中控制患者-通过法律规范的技术实施来提高临床试验中患者的能力的欧洲倡议
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. Clinical outcomes of patients with gastrointestinal malignancies participating in phase I clinical trials [O] . Aaron Denson, Nancy Burke, Georgine Wapinsky, -1

机译：参加I期临床试验的胃肠道恶性肿瘤患者的临床结局
7. Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials [O] . 2016

机译：胃肠道间质瘤患者一期临床试验的临床结果

Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials

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