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首页> 外文期刊>American journal of dentistry >The relative clinical efficacy of three 0.454% stannous fluoride dentifrices for the treatment of gingivitis over 3 months
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The relative clinical efficacy of three 0.454% stannous fluoride dentifrices for the treatment of gingivitis over 3 months

机译：三个0.454％氟化氟胺牙必霉菌的相对临床疗效在3个月内治疗牙龈炎

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Purpose: To assess the safety and efficacy of three stannous fluoride (SnF2) dentifrices in the reduction of gingivitis versus a negative control dentifrice. Methods: This was a randomized, controlled, double-blind, four-treatment parallel group study. 120 healthy adult volunteers with established gingivitis were enrolled and randomly assigned to one of four dentifrice treatment groups (30/group): 0.454% SnF2 + citrate dentifrice A; 0.454% SnF2 + sodium hexametaphosphate dentifrice B; 0.454% SnF2 + pyrophosphate dentifrice C; or 0.76% sodium monofluorophosphate negative control group. Subjects brushed with their assigned dentifrice and an assigned regular manual toothbrush (Oral-B Indicator) for 1 minute twice daily for 12 weeks. Number of gingival bleeding sites and Loe-Silness Gingival Index (LSGI) scores were assessed at baseline and at Weeks 2, 4 and 12. Results: 120 subjects were enrolled and 112 completed the trial. Subjects had an average age (SD) of 39.31 (14.5) years; 67% of subjects were female. Overall baseline means (SD) were 81.2 (25.6) for number of bleeding sites and 1.51 (0.197) for mean LSGI score. Baseline disease levels were balanced across all treatment groups. At Week 2, SnF2 dentifrices A and B demonstrated a significant reduction in gingival bleeding sites versus the negative control; however, SnF2 dentifrice C was not significantly different from the negative control (P= 0.15). At Weeks 4 and 12, all SnF2 dentifrices demonstrated a significant gingival bleeding site reduction versus the negative control (P dentifrice B > dentifrice C for reduction in gingival bleeding sites (P< 0.001). The same trends were seen for LSGI scores.
机译：目的：评估三个氟化硅酸盐（SNF2）洁齿剂在牙龈炎的减少中的安全性和功效，对阴性对照洁齿剂。方法：这是一项随机，受控，双盲，四治疗并联组研究。 120名健康成年志愿者与已建立的牙龈炎进行注册并随机分配给四个牙本菌治疗组（30 /组）中的一种：0.454％SNF2 +柠檬酸酯洁齿剂A; 0.454％SNF2 +六偏磷酸钠牙本质B; 0.454％SNF2 +焦磷酸牙本质C;或0.76％单氟磷酸钠阴性对照组。受试者用其指定的洁齿剂和分配的常规手动牙刷（Oral-B指示器）每天每天两次，每天两次，12周。在基线和第2,4和12周内评估牙龈出血网站和LoE-Silnesgival指数（LSGI）评分的数量。结果：注册了120名受试者，112人完成试验。受试者平均年龄（SD）为39.31（14.5）年; 67％的受试者是女性。整体基线意味（SD）为81.2（25.6），适用于出血位点，1.51（0.197），用于平均LSGI得分。所有治疗组的基线疾病水平平衡。第2周，SNF2洁齿剂A和B显示牙龈出血位点的显着降低与阴性对照;然而，SNF2牙本菌C与阴性对照没有显着不同（P = 0.15）。在第4周和第12周，所有SNF2洁齿剂都证明了显着的牙龈出血部位减少与阴性对照（P洁Dentifrice b>洁齿剂C进行牙龈出血位点（P <0.001）。对于LSGI评分来说是相同的趋势。

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