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首页> 外文期刊>American Journal of Pathology: Official Publication of the American Association of Pathologists >Age-Related Pathology Associated with H1N1 A/California/07/2009 Influenza Virus Infection
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Age-Related Pathology Associated with H1N1 A/California/07/2009 Influenza Virus Infection

机译：与H1N1 A / CALIFORNIA / 07/2009流感病毒感染相关的年龄相关病理学

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摘要

Influenza virus infection causes a spectrum of diseases, ranging from mild upper respiratory tract infection to severe lower respiratory tract infection, that can lead to diffuse alveolar damage, interstitial and airspace inflammation, or acute respiratory failure. Mechanisms instructing disease severity are not completely understood, but host, viral, and bacterial factors influence disease outcome. With age being one host factor associated with a higher risk of severe influenza, we investigated regional pulmonary distribution and severity of pneumonia after 2009 H1N1 influenza virus infection in newly weaned, adult, and aged ferrets to better understand age-dependent susceptibility and pathology. Aged ferrets exhibited greater weight loss and higher rates of mortality than adult ferrets, whereas most newly weaned ferrets did not lose weight but had a lack of weight gain. Newly weaned ferrets exhibited minimal pneumonia, whereas adult and aged ferrets had a spectrum of pneumonia severity. Influenza virus induced pneumonia peaked earliest in adult ferrets, whereas aged ferrets had delayed presentation. Bronchial severity differed among groups, but bronchial pathology was comparable among all cohorts. Alveolar infection was strikingly different among groups. Newly weaned ferrets had little alveolar cell infection. Adult and aged ferrets had alveolar infection, but aged ferrets were unable to clear infection. These different age-related pneumonia and infection patterns suggest therapeutic strategies to treat influenza should be tailored contingent on age.
机译：流感病毒感染导致疾病的光谱，从轻度上呼吸道感染到严重的下呼吸道感染，这可能导致弥漫性肺泡损伤，间质和空体炎症，或急性呼吸衰竭。指示疾病严重程度的机制尚未完全理解，但宿主，病毒和细菌因素会影响疾病结果。随着年龄的是与严重流感风险较高的一个宿主因子，我们在新断奶，成人和老年雪貂中调查了2009年H1N1流感病毒感染后肺炎的区域肺分布和严重程度，以更好地了解年龄依赖性易感性和病理学。老年的雪貂表现出比成人雪貂的更大减肥和更高的死亡率，而大多数新断奶的雪貂没有减肥，但缺乏体重增加。新断奶雪貂表现出最小的肺炎，而成人和老年的雪貂具有巨大的肺炎严重程度。流感病毒诱导肺炎最早在成人雪貂中最早达到顶峰，而老年的雪貂则延迟了介绍。支气管严重程度在群体中不同，但支气管病理学在所有队列中都是相当的。肺泡感染在群体中惊人不同。新断奶的雪貂小肺泡细胞感染。成人和老年的雪貂的肺泡感染，但老年雪貂无法清楚地感染。这些不同的年龄相关的肺炎和感染模式表明治疗甲型流感的治疗策略应根据年龄定制。

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