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首页> 外文期刊>Acta neurobiologiae experimentalis >The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats.
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The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats.

机译：慢性皮质酮对海马星形胶质细胞数量的影响：雄性和雌性Wistar大鼠的比较。

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摘要

Chronic stress an/or glucocorticoid administration produces atrophy of hippocampal neurons. However, evidence of the impact of glucocorticoids on glial cells, especially in both males and females, is limited. In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats. The astrogliosis observed following chronic corticosterone may have implications for extrasynaptic communication and neuron-glia interactions and is similar to changes in the astrocytic population observed in aged rats.
机译：慢性应激和/或糖皮质激素给药会产生海马神经元萎缩。但是，糖皮质激素对神经胶质细胞的影响的证据有限，尤其是在男性和女性中。在本研究中，我们调查了雄性和雌性Wistar大鼠在长期接受皮质酮治疗后的总体重百分比，海马体积和海马星形胶质细胞数量。男性总体具有较高的左右海马体积，但是皮质酮治疗后对海马体积没有影响。男女的总体重均呈剂量依赖性降低，但雄性大鼠的降低更为明显。皮质酮治疗剂量依赖性地增加了CA1区的星形胶质细胞数量，但没有增加外侧和内侧CA3海马区的星形胶质细胞数量。在雄性和雌性大鼠中，这种增加是相似的。慢性皮质酮治疗后观察到的星形胶质细胞沉着症可能与突触外通讯和神经元-神经胶质细胞相互作用有关，并且类似于在老年大鼠中观察到的星形胶质细胞种群变化。

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