• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats.
【24h】

Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats.

机译：慢性丙戊酸盐治疗对雌性和雄性Wistar大鼠生殖内分泌激素的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Valproate (VPA) has been claimed to induce endocrine disorders in both sexes in humans. There is sparse information regarding the mechanisms behind these disturbances. By using an animal model, we wanted to study the effect of valproate on hormonal function in non-epileptic rats. Female rats were given 0 (vehicle control, n=15), 200mg/kg (n=15), or 300mg/kg (n=20) valproate twice daily by gavage for 90 days, resulting in mean valproate concentrations within the therapeutic range 4-6h after the last dose given. Serum testosterone concentrations remained unchanged, while estradiol levels were significantly reduced in both treatment groups, leading to significantly increased testosterone/estradiol ratios. Follicle stimulating hormone (FSH) levels remained unaltered in valproate treated rats, whereas the luteinizing hormone (LH) concentrations were reduced at the lowest valproate dose. Male rats received 0 (vehicle control, n=15), 200mg/kg (n=15), or 400mg/kg (n=20) valproate twice daily by gavage for 90 days, resulting in mean valproate concentrations within the therapeutic range 4-6h after the last dose. Serum testosterone levels were not significantly changed, but there was a highly significant increase in FSH and LH concentrations at the high dose. In conclusion, the study demonstrates a drug-induced effect of valproate on endocrine function in both male and female rats. The results indicate that the drug exerts its effect primarily at the gonadal level, although a centrally mediated effect cannot be ruled out.
机译：据称丙戊酸盐（VPA）可在人类的两性中诱发内分泌失调。关于这些干扰背后的机制的信息很少。通过使用动物模型，我们想研究丙戊酸盐对非癫痫大鼠荷尔蒙功能的影响。雌性大鼠每天两次灌胃90天，分别给予0（媒介物对照组，n = 15），200mg / kg（n = 15）或300mg / kg（n = 20）丙戊酸盐，导致丙戊酸盐平均浓度在治疗范围内最后一次给药后4-6小时。在两个治疗组中，血清睾丸激素浓度保持不变，而雌二醇水平显着降低，从而导致睾丸激素/雌二醇比值显着增加。在丙戊酸盐治疗的大鼠中，促卵泡激素（FSH）的水平保持不变，而在最低丙戊酸盐剂量下，促黄体生成激素（LH）的浓度降低。雄性大鼠通过管饲法连续90天每天两次接受0（媒介物对照组，n = 15），200mg / kg（n = 15）或400mg / kg（n = 20）丙戊酸盐，导致丙戊酸盐平均浓度在治疗范围内4最后一剂后-6h。血清睾丸激素水平没有显着变化，但高剂量时FSH和LH浓度却显着增加。总之，该研究证明了丙戊酸盐对雄性和雌性大鼠内分泌功能的药物诱导作用。结果表明，尽管不能排除中央介导的作用，但该药物主要在性腺水平上发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号