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首页> 外文期刊>Acta neurobiologiae experimentalis >Electrophysiological description of mechanisms determining synaptic transmission and its modulation.
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Electrophysiological description of mechanisms determining synaptic transmission and its modulation.

机译：确定突触传递及其调节机制的电生理学描述。

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摘要

Signal integration in neurons is a complex process that depends on e.g. the kinetics of synaptic currents, distribution of synaptic connections as well as passive and excitatory membrane properties. The time course of synaptic currents is largely determined by the kinetics of the postsynaptic receptors and the time course of synaptic neurotransmitter concentration. The analysis of current responses to rapid agonist applications provides the means to study the ligand-gated receptor gating but experimentally based estimation of neurotransmitter transient at central synapses was an important challenge during the last decade. Both theoretical as well as experimentally based approaches indicated that synaptic agonist transient is very brief, implying that the activation of postsynaptic receptors occurs in conditions of extreme non-equilibrium. Such a dynamic pattern of activation of postsynaptic receptors has a crucial impact not only on the kinetics of synaptic currents but also on their susceptibility to pharmacological modulation.
机译：神经元中的信号整合是一个复杂的过程，取决于例如突触电流的动力学，突触连接的分布以及被动和兴奋性膜的性质。突触电流的时程主要由突触后受体的动力学和突触神经递质浓度的时程决定。对快速激动剂应用的当前反应的分析提供了研究配体-门控受体门控的方法，但是在过去的十年中，基于实验的中枢突触神经递质瞬态的估计是一个重要的挑战。理论和实验方法均表明，突触激动剂瞬变非常短暂，这意味着突触后受体的激活发生在极端的非平衡条件下。突触后受体激活的这种动态模式不仅对突触电流的动力学而且对它们对药理学调制的敏感性都具有至关重要的影响。

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