Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice

Garbani M.; Xia W.; Rhyner C.; Prati M.; Scheynius A.; Malissen B.; Engqvist H.; Maurer M.; Crameri R.; Terhorst D.

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Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice

机译：装载过敏寿锶掺杂的羟基磷灰石球体改善了小鼠的过敏原特异性免疫疗法

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BackgroundImmunomodulatory interventions play a key role in the treatment of infections and cancer as well as allergic diseases. Adjuvants such as micro- and nanoparticles are often added to immunomodulatory therapies to enhance the triggered immune response. Here, we report the immunological assessment of novel and economically manufactured microparticle adjuvants, namely strontium-doped hydroxyapatite porous spheres (SHAS), which we suggest for the use as adjuvant and carrier in allergen-specific immunotherapy (ASIT).

机译：Backgroundmunomodulatory干预措施在治疗感染和癌症以及过敏性疾病中起着关键作用。诸如微型和纳米颗粒的佐剂通常被添加到免疫调节疗法中以增强触发的免疫应答。在这里，我们报告了新型和经济制造的微粒佐剂的免疫学评估，即掺杂锶羟基磷灰石多孔球（SANA），我们建议使用在过敏原特异性免疫疗法（SANIT）中用作佐剂和载体。

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来源
《Allergy》 |2017年第4期|共9页
作者
Garbani M.; Xia W.; Rhyner C.; Prati M.; Scheynius A.; Malissen B.; Engqvist H.; Maurer M.; Crameri R.; Terhorst D.;
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作者单位

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Pl Zurich Switzerland;

Uppsala Univ Appl Mat Sci Angstrom Lab Dept Engn Sci Uppsala Sweden;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Pl Zurich Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Pl Zurich Switzerland;

Karolinska Inst Dept Clin Sci &

Educ Stockholm Sweden;

UM2 Aix Marseille Univ INSERM U1104 CNRS UMR7280 CIML Marseille 9 France;

Uppsala Univ Appl Mat Sci Angstrom Lab Dept Engn Sci Uppsala Sweden;

Charite Dept Dermatol &

Allergy Allergie Ctr Charite Berlin Germany;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Pl Zurich Switzerland;

UM2 Aix Marseille Univ INSERM U1104 CNRS UMR7280 CIML Marseille 9 France;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
allergy model; dendritic cells; immunotherapy; microparticles;

机译：过敏模型;树突状细胞;免疫疗法;微粒;

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专利

1. Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice [J] . Garbani M., Xia W., Rhyner C., Allergy . 2017,第4期

机译：装载过敏寿锶掺杂的羟基磷灰石球体改善了小鼠的过敏原特异性免疫疗法
2. Tolerance induction by prophylactic epicutaneous allergen-specific immunotherapy in a preclinical model of Hymenoptera venom-sensitized mice [J] . Schuppe M., Kiselmann C., Dobler D., Experimental dermatology . 2019,第3期

机译：预防性面膜过敏原特异性免疫治疗Hymenoptera血管敏化小鼠临床前模型的耐受性
3. Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice. [J] . Dioszeghy V, Mondoulet L, Dhelft V, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第10期

机译：表皮免疫疗法可导致树突状细胞通过完整的皮肤快速吸收变应原，并下调致敏小鼠的变应原特异性反应。
4. ALLERGEN-SPECIFIC IMMUNOTHERAPY AND ATOPIC DERMATITIS [C] . Douglas J. DeBoer Conference of the American Animal Hospital Association(2013 :Phoenix(US)) . 2014

机译：特异性免疫疗法和特应性皮炎
5. Exploring the relationships between interfacial compositions of cationic micelles, micellar growth and the sphere-to-rod transition by the chemical trapping method. [D] . Geng, Yan. 2003

机译：通过化学捕集方法探索阳离子胶束的界面组成，胶束生长与球-杆过渡之间的关系。
6. A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects [O] . Rui Zhao, Siyu Chen, Wanlu Zhao, 2020

机译：一种生物陶瓷支架由锶掺杂的三维羟基磷灰石晶须组成可增强骨质疏松性缺损中的骨再生
7. Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice [O] . Garbani, M, Xia, W, Rhyner, C, 2017

机译：负载过敏原的掺锶羟基磷灰石球改善了小鼠的过敏原特异性免疫治疗

Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice

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