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A prospective microbiome‐wide association study of food sensitization and food allergy in early childhood

机译：幼儿食品致敏与食物过敏的前瞻性微生物组合研究

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摘要

Abstract Background Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. Methods Intestinal microbiome samples were collected at age 3‐6 months in children participating in the follow‐up phase of an interventional trial of high‐dose vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food allergy was defined as caretaker report of healthcare provider‐diagnosed allergy to the above foods prior to age 3 with evidence of IgE sensitization. Analysis was performed using Phyloseq and DES eq2; P ‐values were adjusted for multiple comparisons. Results Complete data were available for 225 children; there were 87 cases of food sensitization and 14 cases of food allergy. Microbial diversity measures did not differ between food sensitization and food allergy cases and controls. The genera Haemophilus (log 2 fold change ?2.15, P =.003), Dialister (log 2 fold change ?2.22, P =.009), Dorea (log 2 fold change ?1.65, P =.02), and Clostridium (log 2 fold change ?1.47, P =.002) were underrepresented among subjects with food sensitization. The genera Citrobacter (log 2 fold change ?3.41, P =.03), Oscillospira (log 2 fold change ?2.80, P =.03), Lactococcus (log 2 fold change ?3.19, P =.05), and Dorea (log 2 fold change ?3.00, P =.05) were underrepresented among subjects with food allergy. Conclusions The temporal association between bacterial colonization and food sensitization and allergy suggests that the microbiome may have a causal role in the development of food allergy. Our findings have therapeutic implications for the prevention and treatment of food allergy.
机译：摘要肠道微生物组中的背景改变与哮喘的发展进行了前瞻性;关于微生物组改变在食物过敏的发展中的作用，较少。方法在参与妊娠期间给予的高剂量维生素D的介入试验后续阶段的儿童，肠道微生物样本在3-6个月内收集。在3岁时，评估了对食品（牛奶，鸡蛋，花生，大豆，小麦，核桃）的敏化。食物过敏被定义为医疗保健提供者的看守报告，在3岁之前，患有IgE致敏之前的上述食物的过敏。使用植物和eq2进行分析; P-Values进行了多种比较。结果225名儿童提供完整数据;食物敏感87例食物过敏87例。食物致敏和食物过敏案例和控制之间的微生物多样性措施没有差异。 Genera haemophilus（log 2折叠变化？2.15，p = .003），拨号（log 2折变化？2.22，p = .009），dorea（log 2折变化？1.65，p = .02）和clostridium（ log 2折叠变化？1.47，p = .002）在具有食物致敏的主题中受到称赞。 Genera Citrobacter（log 2折叠变化？3.41，p = .03），Oscillospira（log 2折叠变化？2.80，p = .03），乳酸乳球菌（log 2折变化？3.19，p = .05）和dorea（ Log 2折叠变化？3.00，p = .05）在食物过敏的主题中受到了代表性。结论细菌定植与食物致敏与过敏之间的时间关联表明，微生物组可能在食物过敏的发展中具有因果作用。我们的研究结果对预防和治疗食品过敏的治疗意义。

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  • 来源
    《Allergy》 |2018年第1期|共8页
  • 作者

    Savage Jessica H.; Lee‐Sarwar Kathleen A.; Sordillo Joanne; Bunyavanich Supinda; Zhou Yanjiao; OConnor George; Sandel Megan; Bacharier Leonard B.; Zeiger Robert; Sodergren Erica; Weinstock George M.; Gold Diane R.; Weiss Scott T.; Litonjua Augusto A.;

  • 作者单位

    Division of Rheumatology Immunology and AllergyBrigham and Women's Hospital and Harvard Medical;

    Division of Rheumatology Immunology and AllergyBrigham and Women's Hospital and Harvard Medical;

    Department of Population MedicineHarvard Medical School and Harvard Pilgrim Health CareBoston MA USA;

    Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale;

    The Genome Institute at Washington UniversitySt. Louis MO USA;

    Pulmonary Center and Department of MedicineBoston University School of MedicineBoston MA USA;

    Department of PediatricsBoston Medical CenterBoston MA USA;

    Division of Pediatric AllergyWashington University School of MedicineSt Louis MO USA;

    Kaiser Permanente Southern CaliforniaSan Diego CA USA;

    The Genome Institute at Washington UniversitySt. Louis MO USA;

    The Genome Institute at Washington UniversitySt. Louis MO USA;

    Channing Division of Network MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston;

    Channing Division of Network MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston;

    Channing Division of Network MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Dorea; food allergy; food sensitization; microbiome;

    机译：Dorea;食物过敏;食物敏化;微生物组;

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