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Mechanisms of exercise‐induced bronchoconstriction in athletes: Current perspectives and future challenges

机译:运动诱导的运动员支气管中的机制:当前的观点和未来的挑战

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Abstract The evidence of exercise‐induced bronchoconstriction ( EIB ) without asthma ( EIB w A ) occurring in athletes led to speculate about different endotypes inducing respiratory symptoms within athletes. Classical postulated mechanisms for bronchial obstruction in this population include the osmotic and the thermal hypotheses. More recently, the presence of epithelial injury and inflammation in the airways of athletes was demonstrated. In addition, neuronal activation has been suggested as a potential modulator of bronchoconstriction. Investigation of these emerging mechanisms is of major importance as EIB is a significant problem for both recreational and competitive athletes and is the most common chronic condition among Olympic athletes, with obvious implications for their competing performance, health and quality of life. Hereby, we summarize the latest achievements in this area and identify the current gaps of knowledge so that future research heads toward better defining the etiologic factors and mechanisms involved in development of EIB in elite athletes as well as essential aspects to ultimately propose preventive and therapeutic measures.
机译:摘要运动诱导的支气管内(EIB)的证据,而没有哮喘(EIB W A),在运动员中发生导致诱导诱导运动员内呼吸系统症状的不同内型。该群体中支气管梗阻的经典假设机制包括渗透和热假设。最近,证明了运动员气道中上皮损伤和炎症的存在。此外,已经提出了神经元激活作为支气管混合物的潜在调节剂。对这些新兴机制的调查具有重要意义,因为EIB对于娱乐和竞争运动员来说是一个重要问题,并且是奥运运动员中最常见的慢性状况,具有明显的竞争性能,健康和生活质量的影响。因此,我们总结了该领域的最新成果,并确定了当前的知识差距,使未来的研究领导更好地确定Elite运动员在EIB开发中涉及EIB发展的病因因素和机制,以及最终提出预防性和治疗措施的重要方面。

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