Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model

Asaduzzaman M.; Davidson C.; Nahirney D.; Fiteih Y.; Puttagunta L.; Vliagoftis H.

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Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model

机译：蛋白酶激活的受体-2阻断抑制在慢性鼠哮喘模型中看到的变化

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Background: Proteinase-Activated Receptor-2 (PAR(2)) is a G protein-coupled receptor activated by serine proteinases. We have shown that PAR(2) activation in the airways is involved in the development of allergic inflammation and airway hyperresponsiveness (AHR) in acute murine models. We hypothesized that functional inhibition of PAR(2) prevents allergic inflammation, AHR and airway remodeling in chronic allergic airway inflammation models.

机译：背景：蛋白酶活化受体-2（par（2））是由丝氨蛋白酶激活的G蛋白偶联受体。我们已经表明，航空公司的PAR（2）激活参与急性小鼠模型中过敏性炎症和气道高反应性（AHR）的发展。我们假设PAR（2）的功能性抑制可防止过敏性炎症，AHR和气道重塑在慢性过敏气道炎症模型中。

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来源
《Allergy》 |2018年第2期|共5页
作者
Asaduzzaman M.; Davidson C.; Nahirney D.; Fiteih Y.; Puttagunta L.; Vliagoftis H.;
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作者单位

Univ Alberta Dept Med Pulm Res Grp Edmonton AB Canada;

Univ Alberta Dept Med Pulm Res Grp Edmonton AB Canada;

Univ Alberta Dept Med Pulm Res Grp Edmonton AB Canada;

Univ Alberta Dept Med Pulm Res Grp Edmonton AB Canada;

Univ Alberta Dept Lab Med &

Pathol Edmonton AB Canada;

Univ Alberta Dept Med Pulm Res Grp Edmonton AB Canada;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
airway hyperresponsiveness; airway inflammation; airway remodeling; cockroach extract; proteinase-activated receptor-2;

机译：气道高反应性;气道炎症;气道重塑;蟑螂提取物;蛋白酶激活受体-2;

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专利

1. Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model [J] . Asaduzzaman M., Davidson C., Nahirney D., Allergy . 2018,第2期

机译：蛋白酶激活的受体-2阻断抑制在慢性鼠哮喘模型中看到的变化
2. Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models [J] . Kim Myung Shin, Cho Kyung-Ah, Cho Young Joo, Allergy, Asthma & Immunology Research . 2013,第4期

机译：白细胞介素9阻断剂对小鼠哮喘模型慢性气道炎症的影响
3. Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma [J] . Ahmed Z. El-Hashim, Maitham A. Khajah, Rhema S. Babyson, PLoS One . 2019,第11期

机译：Ang-（1-7）/ mas1受体轴通过阻断SRC介导的EGFR反式激活抑制过敏气道炎症在哮喘的小鼠模型中
4. Role of Proteinase-Activated Receptor-2 on Cyclooxygenase-2 Expression in H. pylori-Infected Gastric Epithelial Cells [C] . JI HYE SEO, KYUNG HWAN KIM, HYEYOUNG KIM Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：蛋白酶激活的受体2对幽门螺杆菌感染的胃上皮细胞中环氧合酶-2表达的作用
5. Immunological and Anti-bronchoconstrictive Properties of the Anti-Asthma Formula ASHMI in a Murine Model of Asthma. [D] . Srivastava, Kamal D. 2011

机译：哮喘小鼠模型中抗哮喘配方ASHMI的免疫学和抗支气管收缩特性。
6. Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models [O] . Myung Shin Kim, Kyung-Ah Cho, Young Joo Cho, 2013

机译：白细胞介素9阻断对小鼠哮喘模型慢性气道炎症的影响
7. IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2 [O] . K. Blease, S. L. Kunkel, C. M. Hogaboam 2001

机译：IL-18调节小鼠模型中的慢性真菌哮喘;推定的涉及疾病的受体-2

Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model

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