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Early‐life gut microbiome and egg allergy

机译：早期肠道微生物和蛋过敏

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Abstract Background Gut microbiota may play a role in egg allergy. We sought to examine the association between early‐life gut microbiota and egg allergy. Methods We studied 141 children with egg allergy and controls from the multicenter Consortium of Food Allergy Research study. At enrollment (age 3 to 16?months), fecal samples were collected, and clinical evaluation, egg‐specific IgE measurement, and egg skin prick test were performed. Gut microbiome was profiled by 16S rRNA sequencing. Analyses for the primary outcome of egg allergy at enrollment, and the secondary outcomes of egg sensitization at enrollment and resolution of egg allergy by age 8?years, were performed using Quantitative Insights into Microbial Ecology, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, and Statistical Analysis of Metagenomic Profiles. Results Compared to controls, increased alpha diversity and distinct taxa ( PERMANOVA P ?=?5.0?×?10 ?4 ) characterized the early‐life gut microbiome of children with egg allergy. Genera from the Lachnospiraceae , Streptococcaceae , and Leuconostocaceae families were differentially abundant in children with egg allergy. Predicted metagenome functional analyses showed differential purine metabolism by the gut microbiota of egg‐allergic subjects (Kruskal‐Wallis P adj ?=?0.021). Greater gut microbiome diversity and genera from Lachnospiraceae and Ruminococcaceae were associated with egg sensitization ( PERMANOVA P ?=?5.0?×?10 ?4 ). Among those with egg allergy, there was no association between early‐life gut microbiota and egg allergy resolution by age 8?years. Conclusion The distinct early‐life gut microbiota in egg‐allergic and egg‐sensitized children identified by our study may point to targets for preventive or therapeutic intervention.
机译：抽象背景肠道微生物群可能在蛋过敏中发挥作用。我们试图检查早期肠道微生物群和鸡蛋过敏之间的关联。方法我们研究了141名儿童鸡蛋过滤器，来自多中心的食物过敏研究研究。在注册（3至16岁以下），收集了粪便样本，并进行了临床评价，特异性IgE测量和蛋皮刺试验。通过16S rRNA测序来分析肠道微生物组。分析鸡蛋过敏症的主要结果，以及8岁以上鸡蛋过敏的鸡蛋过敏的鸡蛋致敏的二次结果是使用定量见解进行微生物生态学，通过重建未观察状态来进行群体，偏心细胞谱的统计分析。结果与对照相比，α多样性和不同的分类群增加（alplenova p？=？5.0？×10？4），其特征在于鸡蛋过敏的儿童早期肠道微生物微生物。来自Lachnospiraceae，Strepcoccaceae和Leuconostocaceae家族的属于鸡蛋过敏的儿童差异丰富。预测的蛋白酶官能分析显示蛋过敏受试者的肠道微生物（Kruskal-wallis p adj =Δ= 0.021）的差异嘌呤代谢。从Lachnospiraceae和Ruminococcaceae的更大的肠道微生物多样性和Genera与蛋敏化有关（alperova p？= 5.0？×10？4）。在鸡蛋过敏的那些中，早期肠道微生物和鸡蛋过敏分辨率之间没有关联8岁？年。结论我们研究发现的蛋清过敏性和蛋敏感的儿童中的不同早期肠道微生物可能指向预防或治疗干预的目标。

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  • 来源
    《Allergy》 |2018年第7期|共10页
  • 作者

    Fazlollahi M.; Chun Y.; Grishin A.; Wood R. A.; Burks A. W.; Dawson P.; Jones S. M.; Leung D. Y. M.; Sampson H. A.; Sicherer S. H.; Bunyavanich S.;

  • 作者单位

    Department of Genetics and Genomic SciencesIcahn School of Medicine at Mount SinaiNew York NY USA;

    Department of Genetics and Genomic SciencesIcahn School of Medicine at Mount SinaiNew York NY USA;

    Division of Pediatric Allergy and ImmunologyIcahn School of Medicine at Mount SinaiNew York NY USA;

    Department of PediatricsJohns Hopkins UniversityBaltimore MD USA;

    Department of PediatricsUniversity of North CarolinaChapel Hill NC USA;

    Emmes CorporationRockville MD USA;

    Department of PediatricsUniversity of Arkansas for Medical SciencesLittle Rock AR USA;

    Department of PediatricsNational Jewish HealthDenver CO USA;

    Division of Pediatric Allergy and ImmunologyIcahn School of Medicine at Mount SinaiNew York NY USA;

    Division of Pediatric Allergy and ImmunologyIcahn School of Medicine at Mount SinaiNew York NY USA;

    Department of Genetics and Genomic SciencesIcahn School of Medicine at Mount SinaiNew York NY USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    egg allergy; egg sensitization; food allergy; microbiome; purine;

    机译：蛋过敏;蛋敏化;食物过敏;微生物组;嘌呤;

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