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首页> 外文期刊>Allergy >Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer
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Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

机译：通过微阵列在马匹中的分子过敏原揭示荞麦作为频繁敏化剂的FAG E 2

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摘要

Abstract Background Companion animals are also affected by IgE‐mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles. Methods Custom‐designed allergen microarray was produced on the basis of the Immuno CAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity. The included horse patients were diagnosed for eczema due to insect bite hypersensitivity, chronic coughing, recurrent airway obstruction and urticaria or were clinically asymptomatic. Results Horses showed individual IgE‐binding patterns irrespective of their health status, indicating sensitization. In contrast to European and Japanese human sensitization patterns, frequently recognized allergens were Aln g 1 from alder and Cyn d 1 from Bermuda grass, likely due to specific respiratory exposure around paddocks and near the ground. The most prevalent allergen for 72.5% of the tested horses (37/51) was the 2S‐albumin Fag e 2 from buckwheat, which recently gained importance not only in human but also in horse diet. Conclusion In line with the One Health concept, covering human health, animal health and environmental health, allergen microarrays provide novel information on the allergen sensitization patterns of the companion animals around us, which may form a basis for allergen‐specific preventive and therapeutic concepts.
机译：摘要背景伴侣也受到IgE介导的过敏的影响，但引发分子很大程度上是未知的。我们旨在精炼过敏原微阵列，探讨马匹的敏感，并将其与人IgE反应性谱进行比较。方法采用定制设计的过敏原微阵列是在含有131个过敏原的免疫帽ISAC技术的基础上制备。从欧洲或日本源于51匹马的血清进行了特定的IgE反应性。由于昆虫叮咬过敏，慢性咳嗽，复发气道阻塞和荨麻疹或临床上无症状，所包括的马患者被诊断为湿疹。结果马显示了无关其健康状况，表明敏感性的单独绑定模式。与欧洲和日本人类敏化模式相比，经常公认的过敏原来自艾尔德和百慕大草的Cyn D 1的Aln G 1，可能是由于围绕围场和地面附近的特定呼吸暴露。最普遍的过敏原于72.5％的测试马（37/51）是来自荞麦的2S-白蛋白FAG E 2，最近不仅在人类中获得了重要性，也是马饮食。结论符合对人类健康，动物健康和环境健康的一个健康概念，过敏原微阵列提供了关于我们周围伴侣动物的过敏原致敏模式的新信息，这可能是一种特异性预防性和治疗概念的基础。

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  • 来源
    《Allergy》 |2018年第7期|共11页
  • 作者

    Einhorn L.; Hofstetter G.; Brandt S.; Hainisch E. K.; Fukuda I.; Kusano K.; Scheynius A.; Mittermann I.; Resch‐Marat Y.; Vrtala S.; Valenta R.; Marti E.; Rhyner C.; Crameri R.; Satoh R.; Teshima R.; Tanaka A.; Sato H.; Matsuda H.; Pali‐Sch?ll I.; Jensen‐Jarolim E.;

  • 作者单位

    The interuniversity Messerli Research InstituteUniversity of Veterinary Medicine ViennaVienna;

    The interuniversity Messerli Research InstituteUniversity of Veterinary Medicine ViennaVienna;

    Research Group OncologyUniversity of Veterinary Medicine ViennaVienna Austria;

    Research Group OncologyUniversity of Veterinary Medicine ViennaVienna Austria;

    Racehorse HospitalJapan Racing AssociationMikoma Japan;

    Racehorse HospitalJapan Racing AssociationMikoma Japan;

    Science for Life LaboratoryKarolinska Institutet and Sachs’ Children and Youth HospitalStockholm;

    Institute of Pathophysiology and Allergy ResearchMedical University of ViennaVienna Austria;

    Institute of Pathophysiology and Allergy ResearchMedical University of ViennaVienna Austria;

    Institute of Pathophysiology and Allergy ResearchMedical University of ViennaVienna Austria;

    Institute of Pathophysiology and Allergy ResearchMedical University of ViennaVienna Austria;

    Department of Clinical Research and Veterinary Public HealthUniversity of BernBern Switzerland;

    Swiss Institute for Allergy and Asthma Research (SIAF)Davos Switzerland;

    Swiss Institute for Allergy and Asthma Research (SIAF)Davos Switzerland;

    Division of Food Function ResearchNational Agriculture and Food Research OrganizationTsukuba Japan;

    National Institute of Health SciencesTokyo Japan;

    Laboratory of Comparative Animal MedicineTokyo University of Agriculture and TechnologyFuchu Japan;

    Laboratory of Veterinary Molecular Pathology and TherapeuticsTokyo University of Agriculture and;

    Laboratory of Veterinary Molecular Pathology and TherapeuticsTokyo University of Agriculture and;

    The interuniversity Messerli Research InstituteUniversity of Veterinary Medicine ViennaVienna;

    The interuniversity Messerli Research InstituteUniversity of Veterinary Medicine ViennaVienna;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergen; microarray; component‐resolved diagnosis; horse; IgE; ISAC; molecular;

    机译：过敏原;微阵列;组分分辨诊断;马;IgE;ISAC;分子;

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