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The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

机译：哮喘 - 鼻炎多药物与青少年和成人的IgE聚敏化有关

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摘要

Abstract Background Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. Methods IgE reactivity to 64 micro‐arrayed aeroallergen molecules was determined with the Me DALL ‐chip in samples from the French EGEA study (n = 840, age = 40.7 ± 17.1) and the Swedish population‐based birth cohort BAMSE (n = 786, age = 16 ± 0.26). The age‐ and sex‐adjusted associations between the number of IgE‐reactive allergen molecules (≥0.3 ISU ) and the asthma‐rhinitis phenotypes were assessed using a negative binomial model. Results Groups representing 4 phenotypes were identified: no asthma‐no rhinitis (A?R?; 30% in EGEA and 54% in BAMSE ), asthma alone (A+R?; 11% and 8%), rhinitis alone (A?R+; 15% and 24%) and asthma‐rhinitis (A+R+; 44% and 14%). The numbers of IgE‐reactive aeroallergen molecules significantly differed between phenotypes (median in A?R?, A+R?, A?R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE ). As compared to A?R? subjects, the adjusted ratio of the mean number of IgE‐reactive molecules was higher in A+R+ than in A+R? or A?R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE ). Conclusion The A+R+ phenotype combined the sensitization pattern of both the A?R+ and A+R? phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.
机译：摘要背景儿童有多漏脂哮喘和鼻炎显示IgE聚敏化对几个过敏原子来源。这种关联在使用定义的过敏原分子的青少年和成人中仍然很差。我们研究了IGE致敏模式，朝着成人和青少年的宽面板宽面板，重点关注哮喘和鼻炎多重药物的个体。方法使用法国EGEA研究的样品中的ME DALL-CHIP测定IGE反应性与64个微阵列的气雾剂分子测定（n = 840，年龄= 40.7±17.1）和瑞典人群的诞生队列BAMSE（n = 786，年龄= 16±0.26）。使用负二进制型评估IgE-反应性过敏原分子数（≥0.3isu）和哮喘鼻炎表型之间的年龄和性别调整的关联。结果鉴定了代表4种表型的群体：没有哮喘 - 没有鼻炎（A？R？;在EGEA的30％和54％的BAMSE），单独哮喘（A + R？; 11％和8％），单独的鼻炎（A？ R +; 15％和24％）和哮喘鼻炎（A + R +; 44％和14％）。表型的IgE-反应性气动原分子的数量显着不同（中位数，在αr+，a + r =α，aαr +和a + r + + r + + r + r +：0，1,2和7之间，0,0,3和5在Bamse）。与a？r相比？受试者，IgE反应性分子的平均数量的调节比率高于A + R + + +或者在BAMSE中的EGEA和7.2,0.7和4.8中的αr +（10.0,5.4和5.0）。结论A + R +表型组合Aαr +和A + R的敏化模式。表型。该多功能多剂量聚敏化表型似乎是普遍大定的各种年龄和过敏性环境，并且可能与特定机制相关。

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  • 来源
    《Allergy》 |2018年第7期|共12页
  • 作者

    Siroux V.; Ballardini N.; Soler M.; Lupinek C.; Boudier A.; Pin I.; Just J.; Nadif R.; Anto J. M.; Melen E.; Valenta R.; Wickman M.; Bousquet J.;

  • 作者单位

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Division of ImmunopathologyMedical University of ViennaVienna Austria;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Allergology DepartmentChildren Hospital Armand TrousseauParis France;

    Inserm U1168VIMA: Aging and Chronic Diseases Epidemiological and Public Health;

    ISGLoBALCentre for Research in Environmental Epidemiology (CREAL)Barcelona Spain;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Division of ImmunopathologyMedical University of ViennaVienna Austria;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Inserm U1168VIMA: Aging and Chronic Diseases Epidemiological and Public Health;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergens; epidemiology; multimorbidity; polysensitization; specific IgE;

    机译：过敏原;流行病学;多元化;聚敏化;特定的IgE;

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