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首页> 外文期刊>Allergy >ILC ILC 2 frequency and activity are inhibited by glucocorticoid treatment via STAT STAT pathway in patients with asthma
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ILC ILC 2 frequency and activity are inhibited by glucocorticoid treatment via STAT STAT pathway in patients with asthma

机译：ILC ILC 2频率和活性受到哮喘患者患者的统计数据态途径抑制血糖皮质激素治疗

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摘要

Abstract Background Group 2 innate lymphoid cells ( ILC 2s) were closely associated with asthma. However, there were no perspective studies about the effects of glucocorticoid on ILC 2s in asthma patients. Our objective was to perform a perspective study and evaluate the ILC 2 activity after glucocorticoid therapy in asthma patients. Methods The asthma and asthma with allergic rhinitis patients were treated with glucocorticoid for 3?months. The circulating ILC 2 levels were evaluated. The effects of glucocorticoid on ILC 2s and possible signalling pathways were investigated in?vitro. Results The patients were well‐controlled, and the high ILC 2 levels were significantly decreased at 1 and 3?months after treatment. Peripheral blood monocytes from allergic patients produced dramatic IL ‐5, IL ‐13 and IL ‐9 in response to IL ‐25, IL ‐33 plus IL ‐2, and glucocorticoid significantly decreased their levels. Moreover, ILC 2s were identified to be the predominant source of IL ‐5, IL ‐13 and IL ‐9, and glucocorticoid treatment was able to reverse their high levels. STAT 3, STAT 5, STAT 6, JAK 3 and MEK signalling pathways were proved to be involved in regulating ILC 2 activity under the glucocorticoid treatment. Conclusion The data suggested that glucocorticoid administration could be effective in treating asthma by regulating ILC 2s via MEK / JAK ‐ STAT signalling pathways. This provides a new understanding of glucocorticoid application in regard to allergic diseases.
机译：摘要背景第2组先天淋巴细胞（ILC 2S）与哮喘密切相关。然而，没有关于哮喘患者ILC 2S对ILC 2S的影响的透视研究。我们的目标是进行透视研究，并在哮喘患者糖皮质激素治疗后进行ILC 2活性。方法使用糖皮质激素治疗具有过敏性鼻炎患者的哮喘和哮喘，3个月。评估循环ILC 2水平。研究了糖皮质激素对ILC 2S和可能的信令途径的影响。结果患者受到良好的控制，在治疗后1和3个月，高ILC 2水平显着降低。来自过敏性患者的外周血单核细胞产生戏剧性IL -5，IL -13和IL -9响应于IL -25，IL -33加IL -2和糖皮质激素显着降低了它们的水平。此外，ILC 2S被鉴定为IL -5，IL -13和IL -9的主要来源，糖皮质激素治疗能够逆转其高水平。证明STAT 3，STAT 5，Stat 6，JAK 3和MEK信号传导途径被证明参与在糖皮质激素处理下调节ILC 2活性。结论数据表明，通过MEK / JAK - 统计信号传导途径调节ILC 2S，可以有效地治疗哮喘。这为过敏性疾病提供了对糖皮质激素应用的新了解。

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  • 来源
    《Allergy》 |2018年第9期|共11页
  • 作者

    Yu Q. N.; Guo Y. B.; Li X.; Li C. L.; Tan W. P.; Fan X. L.; Qin Z. L.; Chen D.; Wen W. P.; Zheng S. G.; Fu Q. L.;

  • 作者单位

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Department of RespiratoryThe First Affiliated HospitalGuangzhou China;

    Department of EmergencyGuangdong General HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Department of RespiratoryThe First Affiliated HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

    Department of Clinical ImmunologyThe Third Affiliated HospitalGuangzhou China;

    Otorhinolaryngology HospitalThe First Affiliated HospitalGuangzhou China;

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  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    asthma patient; glucocorticoid; group 2 innate lymphoid cells; inhibition; STAT signalling pathway;

    机译：哮喘患者;糖皮质激素;第2组先天淋巴细胞;抑制;统计信号通路;

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