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Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

机译：接触室内内分泌破坏化学品和儿童哮喘和肥胖症

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摘要

Abstract Background Indoor air contaminants may act as endocrine‐disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren. Methods Data from a cross‐sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated. The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout 1?week. Principal component analysis (PCA) was used to assess the effect of co‐exposure. Associations were estimated by regression coefficients using linear and logistic regression models. Results Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2‐butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, o‐xylene, m/p‐xylene and ethylbenzene were significantly associated with nasal obstruction. A positive association was found between PC1 and the risk of obese asthma (OR?=?1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR?=?1.51, 95% CI 1.28, 1.79). PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low. Conclusions Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity.
机译：摘要背景室内空气污染物可作为内分泌破坏化学品（EDC）。然而，这些污染物会影响健康的程度是知名的。我们的目标是评估EDCS暴露和哮喘之间的关联，哮喘，呼吸道症状和学童肥胖症。方法分析了来自葡萄牙波尔图的20所学校的815名参与者的横截面分析的数据。评估症状，在肺功能下定义哮喘，并计算气道可逆性和体重指数（BMI）。在整个1？周的71个教室中测量了13个挥发性有机化合物和2醛鉴定为EDC的浓度。主要成分分析（PCA）用于评估共曝光的效果。使用线性和逻辑回归模型通过回归系数估计关联。结果在具有哮喘和肥胖的儿童的教室中发现了个体和联合EDCS水平增加。较高水平的己烷，苯乙烯，环己酮，丁基化羟基甲苯和2-丁氧基乙醇与肥胖有关，较高水平的环己酮与儿童BMI增加有关。甲苯，O-二甲苯，M / p-二甲苯和乙苯与鼻塞显着相关。在PC1和肥胖哮喘的风险（或？=？1.43,95％CI 1.01,1.98）以及PC2和超重之间（或？=？1.51,95％CI 1.51,95％CI 1.28,1.79）之间存在阳性关联。 PC1和PC2也与鼻阻塞有关，但PC2与呼吸困难和瘦体重有关，尽管EDC浓度低。结论我们的研究结果进一步支持EDC在哮喘和肥胖发展中的作用。此外，甚至低水平的室内暴露可能会影响哮喘，呼吸系统症状和肥胖症的风险。

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  • 来源
    《Allergy》 |2019年第7期|共15页
  • 作者

    Paciência Inês; Cavaleiro Rufo Jo?o; Silva Diana; Martins Carla; Mendes Francisca; Farraia Mariana; Delgado Luís; de Oliveira Fernandes Eduardo; Padr?o Patrícia; Moreira Pedro; Severo Milton; Barros Henrique; Moreira André;

  • 作者单位

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

    Institute of Science and Innovation in Mechanical Engineering and Industrial Management (INEGI;

    EPIUnitUniversidade do PortoPorto Portugal;

    EPIUnitUniversidade do PortoPorto Portugal;

    EPIUnitUniversidade do PortoPorto Portugal;

    EPIUnitUniversidade do PortoPorto Portugal;

    Servi?o de Imunologia Básica e ClínicaPorto Portugal &

    Centro Hospitalar S?o Jo?oPorto Portugal;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    asthma; children; endocrine‐disrupting chemicals; indoor air; obesity;

    机译：哮喘;儿童;内分泌破坏化学品;室内空气;肥胖;

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