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TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation

机译:TSLP和IL-33相互促进彼此的肺蛋白表达和ILC2受体表达,以增强先天型气道炎症

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摘要

Background The epithelial cell-derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL-33 are consistently associated with adaptive Th2 immune responses in asthma. In addition, TSLP and IL-33 synergistically promoted group 2 innate lymphoid cell (ILC2) activation to induce innate allergic inflammation. However, the mechanism of this synergistic ILC2 activation is unknown.
机译:背景技术上皮细胞衍生的危险信号介质胸腺基质淋巴细胞蛋白(TSLP)和IL-33与哮喘中的适应性Th2免疫应答始终如一。 此外,TSLP和IL-33协同促进的第2组先天淋巴细胞(ILC2)活化,以诱导先天过敏性炎症。 然而,这种协同ILC2激活的机制是未知的。

著录项

  • 来源
    《Allergy》 |2020年第7期|共12页
  • 作者单位

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

    Indiana Univ Sch Med Dept Pediat Wells Ctr Pediat Res Indianapolis IN 46202 USA;

    Mayo Clin Div Allerg Dis Dept Internal Med Rochester MN USA;

    Vanderbilt Univ Sch Med Dept Pathol Microbiol &

    Immunol Nashville TN 37212 USA;

    Vanderbilt Univ Sch Med Div Allergy Pulm &

    Crit Care Med Nashville TN 37212 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Alternaria-extract (Alt-Ext); Group 2 innate lymphoid cells (ILC2); IL-33; TSLP;

    机译:alternaria-萃取物(Alt-ext);第2组先天淋巴细胞(ILC2);IL-33;TSLP;

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