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首页> 外文期刊>ACS Macro Letters >Polymer–Protein Conjugate Particles with Biocatalytic Activity for Stabilization of Water-in-Water Emulsions
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Polymer–Protein Conjugate Particles with Biocatalytic Activity for Stabilization of Water-in-Water Emulsions

机译：具有生物催化活性的聚合物 - 蛋白质缀合物颗粒，用于稳定水 - 水乳液

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摘要

src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-7/acsmacrolett.7b00294/20170712/images/medium/mz-2017-002942_0005.gif">Water-in-water (w/w) emulsions are attractive microcompartmentalized platforms due to their outstanding biocompatibility. To address the main disadvantage of poor stability that hampers their practical application, here we report a novel type of polymer–protein conjugate emulsifier obtained by Schiff base synthesis to stabilize w/w emulsions. In particular, the proposed mild approach benefits the modification of proteins of suitable size and wettability as particulate emulsifiers retaining their bioactivity. As demonstrated in a model system, the methoxy polyethylene glycol (mPEG)-urease conjugate particles anchor at the w/w interfaces, where they serve as an effective emulsifier-combined-catalyst and catalyze the hydrolysis of urea in water to ammonium carbonate. Our study is unique in that it employs bioactive particles to stabilize w/w emulsions. Considering the characteristics of all-aqueous, compartmental and interfacial biocatalysis of the system, it will open up new possibilities in the life sciences.
机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-7/acsmacrolett.7b002/2/20170712/imace/medium/mz -2017-002942_0005.gif“>水 - 水（w / w）乳液是由于其卓越的生物相容性，具有吸引力的微型组分平台。为了解决稳定性较差的主要缺点，妨碍了它们的实际应用，在这里我们报告了一种新型的聚合物 - 蛋​​白质缀合物乳化剂，得到了Schiff碱合合成，稳定了W / W乳液。特别地，所提出的温和方法有益于根据颗粒乳化剂保留其生物活性的颗粒乳化剂的蛋白质的改性。如在模型系统中所示，甲氧基聚乙二醇（MPEG） - 尿液饱和颗粒锚定在W / W界面，其中它们用作有效的乳化剂组合催化剂，并催化尿素水解水中的水解至碳酸铵。我们的研究是独一无二的，它采用生物活性颗粒稳定W / W乳液。考虑到系统的全水，室内和界面生物分析的特点，它将在生命科学中开辟新的可能性。

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  • 来源
    《ACS Macro Letters》 |2017年第7期|共5页
  • 作者

    Long-Hui Xue; Chun-Yan Xie; Shi-Xin Meng; Rui-Xue Bai; Xin Yang; Yaolei Wang; Shu Wang; Bernard P. Binks; Ting Guo; Tao Meng;

  • 作者单位

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Mathematics and Physical Sciences University of Hull Hull HU6 7RX United Kingdom;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

    School of Life Sciences and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 People’s Republic of China;

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  • 正文语种 eng
  • 中图分类 有机化学;
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