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首页> 外文期刊>ACS Macro Letters >Fabricating Tough Interpenetrating Network Cryogels with DNA as the Primary Network for Biomedical Applications
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Fabricating Tough Interpenetrating Network Cryogels with DNA as the Primary Network for Biomedical Applications

机译：用DNA制造坚韧的互穿网络冷冻胶片作为生物医学应用的主要网络

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摘要

This work investigates a sequential strategy to develop DNA-based hydrogel scaffolds with interpenetrating polymeric network. The scaffolds were formed via a two-step procedure. First, a covalently cross-linked DNA-based cryogel was formed by the chemical reaction between DNA strands and a bifunctional cross-linker, polyethylene glycol diepoxide at subzero temperatures. In the second step, alginate chains were absorbed into the preformed macroporous DNA cryogel network, followed by ionic cross-linking with divalent calcium ions. The individual and synergistic effects of covalent and ionic cross-linkings on mechanical and physical properties of the IPN cryogel were tested. The IPN cryogels were able to sustain large deformations higher than 95% of strain under compressive forces without exhibiting any failure. Addition of a physically cross-linked alginate network to the covalently linked DNA cryogel significantly enhanced its toughness and energy dissipation compared to the covalent network alone. The formulated hydrogels also exhibited excellent biocompatibility with human stem cells. Overall, this DNA-based IPN cryogel has the potential to be used as a biomaterial scaffold for a diverse range of tissue engineering applications.
机译：该工作研究了用互穿聚合物网络开发基于DNA的水凝胶支架的顺序策略。通过两步方法形成支架。首先，通过DNA链和双官能交联剂之间的化学反应形成共价交联的DNA的冷冻凝胶，在亚零温度下的聚乙二醇杀菌剂。在第二步中，藻酸盐链被吸收到预制的大孔DNA冷冻凝胶网络中，然后与二价钙离子进行离子交联。测试了Coperate和离子交联对IPN冷冻凝胶的机械和物理性质的个体和协同作用。 IPN Cryogels能够在压缩力下维持高于95％的菌株的大变形而不表现出任何故障。与单独的共价网络相比，将物理交联的藻酸盐网络添加到共价连接的DNA Cryogel上显着提高了其韧性和能量耗散。配制的水凝胶还与人干细胞表现出优异的生物相容性。总的来说，这种基于DNA的IPN Cryogel具有用于各种组织工程应用的生物材料脚手架。

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  • 来源
    《ACS Macro Letters》 |2020年第9期|共7页
  • 作者

    Basu Sayantani; Johl Rea; Pacelli Settimio; Gehrke Stevin; Paul Arghya;

  • 作者单位

    Univ Kansas Dept Chem &

    Petr Engn Sch Engn Lawrence KS 66045 USA;

    Univ Kansas Dept Chem &

    Petr Engn Sch Engn Lawrence KS 66045 USA;

    Univ Texas San Antonio Dept Biomed Engn San Antonio TX 78249 USA;

    Univ Kansas Dept Chem &

    Petr Engn Sch Engn Lawrence KS 66045 USA;

    Univ Western Ontario Dept Chem &

    Biochem Engn Dept Chem London ON N6A 5B9 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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