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Advances in patented interpenetrating polymeric networks for biomedical applications

机译：用于生物医学应用的专利互穿聚合物网络的进展

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An interpenetrating polymeric network (IPN) represents a complex crosslinked polymeric system wherein two or more polymer networks are noncovalently intertwined and essentially require breaking of chemical bonds to separate the networks. Subsequently, a full-IPN refers to an IPN with all the polymer networks chemically crosslinked while a semi-IPN consists of at least one polymer network noncrosslinked [1-3]. In common saying, the IPNs are capable of providing best of the two worlds with no strings attached. A significant rise in the patenting (applications as well as granted) of IPNs for biomedical applications has been noted recently. Such applications include, but are not limited to, drug and growth factor delivery, tissue engineering, regenerative medicine, cell/organ culture, space-filling and bioreplacement. Similar to the applications, the composition in these IPN matrices vary to a large extent (applicability plus patentability) wherein various permutations and combinations of, but not limited to, hydrophilic and hydrophobic polymers; natural, synthetic and semi-synthetic polymers; pre- and postsynthesized polymers; ionic and neutral polymers; block copolymers; inorganic and organic entities; proteins and peptides; and physical and chemical crosslinking have been employed [1-3]. This editorial provides a brief account of most recent patents filed for biomedical application of IPNs and uses thereof.
机译：互穿聚合物网络（IPN）代表复杂的交联聚合物系统，其中两个或更多个聚合物网络是非共价交织的，并且基本上需要破碎化学键以分离网络。随后，全IPN是指具有化学交联的所有聚合物网络的IPN，而半IPN由至少一个聚合物网络非折叠[1-3]。俗话说，IPNS能够提供最好的两个世界，没有附加琴弦。最近已经注意到用于生物医学应用程序的专利（申请以及授权）的专利（申请和授权）的显着增加。这些应用包括但不限于药物和生长因子输送，组织工程，再生医学，细胞/器官培养，空间填充和生物缩进。类似于应用，这些IPN矩阵中的组合物在很大程度上变化（适用性加可专利性），其中各种排列和组合，但不限于亲水和疏水聚合物;天然，合成和半合成聚合物;预先和后合聚合物;离子和中性聚合物;嵌段共聚物;无机和有机实体;蛋白质和肽;已经采用了物理和化学交联[1-3]。这编辑编辑为IPN和用途的生物医学应用程序提出了最新的专利简要说明。

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