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首页> 外文期刊>ACS Macro Letters >100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery
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100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery

机译：大分子科学观点100周年：生物刺激敏感聚合物前药和肿瘤特异性药物递送的纳米颗粒

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摘要

The development of smart polymer vehicles to carry and release cytotoxic drugs to tumor tissues and cells while reducing the exposure of drugs in the blood and healthy organs is a highly challenging task with continuously growing interest from multiple fields, including polymer science, pharmaceutical science, nanotechnology, and clinical oncology. Inspired by the unique tumor microenvironment, such as mild acidity and overexpressed enzymes, functional polymer prodrugs and nanoparticles with reversible charge, detachable PEG shell, activatable ligand, and switchable size have been designed to enhance tumor deposition, tumor penetration, tumor cell uptake, and tumoral drug release. Utilizing biological signals inside tumor cells, such as acidic endo/lysosomal pH, elevated glutathione levels, and reactive oxygen species, responsive polymer prodrugs and nanoparticles with good extracellular stability but fast intracellular disintegration have been engineered for specific intracellular drug release. These biological stimuli-sensitive polymer prodrugs and nanoparticles have shown superior specificity and therapeutic efficacy to nonsensitive counterparts and, in certain cases, even clinically approved systems in varying tumor models. In this Viewpoint, design strategies and recent advances of biological stimuli-responsive polymer prodrugs and nanoparticles for tumor-specific drug delivery will be highlighted, and their challenges and future perspectives will be discussed.
机译：智能聚合物载体的发展在血液组织和细胞中携带和释放细胞毒性药物，同时降低血液和健康器官的药物暴露是一种高度挑战的任务，具有来自多个领域的不断增长的兴趣，包括聚合物科学，制药科学，纳米技术和临床肿瘤学。由独特的肿瘤微环境的启发，例如温和的酸度和过表达酶，具有可逆电荷，可拆卸的PEG壳，可活性配体和可切换尺寸的功能性聚合物前药和纳米颗粒已经设计成增强肿瘤沉积，肿瘤渗透，肿瘤细胞吸收，以及肿瘤药物释放。利用肿瘤细胞内的生物信号，例如酸性腹腔/溶酶体pH，升高的谷胱甘肽水平和反应性氧，具有良好的细胞外稳定性但快速细胞内崩解的响应性聚合物前药和纳米颗粒已经针对特定的细胞内药物释放。这些生物刺激敏感的聚合物前药和纳米颗粒已经显示出优异的特异性和治疗效果对非敏感对应物，并且在某些情况下，甚至在不同肿瘤模型中临床批准的系统。在这种观点来看，将突出设计策略和生物刺激聚合物前药和纳米颗粒的近期进步，将突出显示肿瘤特异性药物递送，并将讨论其挑战和未来的观点。

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  • 来源
    《ACS Macro Letters》 |2020年第9期|共11页
  • 作者

    Sun Huanli; Zhong Zhiyuan;

  • 作者单位

    Soochow Univ Biomed Polymers Lab Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Soochow Univ Biomed Polymers Lab Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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