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首页> 外文期刊>Current topics in nutraceutical research >EFFECT OF PHOSPHORUS MANIPULATION ON NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) DEVELOPMENT IN RATS MAINTAINED ON HIGH FRUCTOSE OR HIGH FAT DIET
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EFFECT OF PHOSPHORUS MANIPULATION ON NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) DEVELOPMENT IN RATS MAINTAINED ON HIGH FRUCTOSE OR HIGH FAT DIET

机译：磷操纵对高果糖或高脂饮食维持大鼠非酒精性脂肪肝病（NAFLD）发育的影响

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With the increase of Non-Alcoholic Fatty Liver Disease (NAFLD) prevalence, research has focused on its pathophysiology and novel preventive and therapeutic targets. The role of phosphorus (P) manipulation in fructose and fat-induced NAFLD was investigated. Two experiments were performed on 6-week-old male Sprague-Dawley rats with 5 random groups in each, maintained on their diets for 9 weeks. Experiment1: Control diet (0.3%P), high fructose diet with 0.15, 0.3, 0.6 and 0.9%P. Experiment2: Control diet (0.3%P), high fat diet with 0.018, 0.075, 0.15 and 0.3%P. Food intake and body weight were measured twice/week. Weight gain of the high fructose groups decreased, probably due to a reduction in energy efficiency rather than that of energy intake. In the high fat diets, P depletion (0.15%) reduced weight gain, food intake and energy efficiency while liver dry weight (%) and fat (%) in dry weight were higher. In high fructose groups, microvascular steatosis was greater in the high phosphorus groups (0.6 and 0.9%) though hepatic fat content was not affected by P content of the diet. Whereas micro vascular steatosis of the high fat groups was not affected by phosphorus content of the diet. Phosphorus can be considered as another parameter that impacts the development of NAFLD, especially in high fructose diets.
机译：随着非酒精性脂肪肝病（NAFLD）患病率的增加，研究专注于其病理生理学和新型预防性和治疗靶标。研究了磷（P）操纵在果糖和脂肪诱导的NAFLD中的作用。在6周龄雄性Sprague-Dawley大鼠上进行两次实验，每次5种随机组，维持在其饮食中9周。实验1：控制饮食（0.3％p），高果糖饮食，0.15,0.3,0.6和0.9％p。实验2：控制饮食（0.3％P），高脂肪饮食，0.018,0.075,0.15和0.3％p。食物摄入量和体重是两次/周测量的。高果糖基团的体重增加降低，可能是由于能量效率的降低而不是能量摄入量的降低。在高脂肪饮食中，P消耗（<0.15％）减轻重量增益，食物摄入和能量效率，而干重的肝脏干重（％）和脂肪（％）较高。在高果糖组中，高磷基团（0.6和0.9％）的微血管脂肪变性虽然肝脂肪含量不受饮食的P含量的影响。虽然高脂肪组的微血管脂肪变性不受饮食磷含量的影响。磷可以被认为是影响NAFLD的发育的另一个参数，特别是在高果糖饮食中。

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