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首页> 外文期刊>American Journal of Veterinary Research >Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions
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Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions

机译：前饮食实践和与人体肠道微生物地区的联系改变对饮食干预的反应

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摘要

Ensuring that gut microbiota respond consistently to prescribed dietary interventions, irrespective of prior dietary practices (DPs), is critical for effective nutritional therapy. To address this, we identified DPassociated gut bacterial taxa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or without dietary restrictions (AMER). When transplanted into gnotobiotic mice, AMER and CRON microbiota responded predictably to CRON and AMER diets but with variable response strengths. An individual's microbiota is connected to other individuals' communities ("metacommunity'') by microbial exchange. Sequentially cohousing AMER-colonized mice with two different groups of CRON-colonized mice simulated metacommunity effects, resulting in enhanced responses to a CRON diet intervention and changes in several metabolic features in AMER animals. This response was driven by an influx of CRON DP-associated taxa. Certain DPs may impair responses to dietary interventions, necessitating the introduction of diet-responsive bacterial lineages present in other individuals and identified using the strategies described.
机译：确保肠道微生物群始终如一的饮食干预措施，而不管事先饮食实践（DPS）都是关键的营养治疗至关重要。为了解决这一点，我们在个人中鉴定了具有足够营养（Cron）或没有饮食限制（Amer）的慢性卡路里限制的慢性卡路里的细菌分类群。当移植到胎虫小鼠时，Amer和Cron Microbiota可预测地响应Cron和Amer饮食，但具有可变响应强度。个人的微生物群通过微生物交换与其他个人的社区（“MetaCommunity”）相互联系起来。依次舒张与两种不同的Cron - 殖民化小鼠模拟MetaComity效应的氨基殖民化小鼠，导致对Cron饮食干预和变化的反应增强了响应在AMER动物中的几种代谢特征中。这种反应是由Cron DP相关分类群的涌入驱动的。某些DPS可能会损害饮食干预的反应，这意味着引入其他个体中存在的饮食响应细菌谱系并使用所述策略鉴定。

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