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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Randomised comparison of uterine artery Doppler and aspirin (100 mg) with placebo in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 2).
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Randomised comparison of uterine artery Doppler and aspirin (100 mg) with placebo in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 2).

机译：未产妇中子宫动脉多普勒和阿司匹林（100毫克）与安慰剂的随机比较：Essai地区阿司匹林单纯婴儿研究（第2部分）。

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To assess the effectiveness of a pre-eclampsia prevention strategy based on routine uterine artery Doppler flow velocity waveform examination during the second trimester of pregnancy, followed by a prescription for 100 mg aspirin in the case of abnormal Doppler findings.Multicentre randomised controlled trial.Eleven centres in the north of France and one in Belgium.One thousand and eight hundred and fifty-three nulliparous women recruited between 14 and 20 weeks of gestation.Randomisation either to undergo a uterine Doppler examination between 22 and 24 week of gestation or to take a placebo. Women with abnormal Doppler waveforms received 100 mg of aspirin daily from Doppler examination through 36 weeks.Pre-eclampsia was defined as hypertension (>/= 140 and/or 90 mmHg) associated with proteinuria (>/= 0.5 g/L).One thousand two hundred and fifty-three women (67%) were randomised into the systematic Doppler group and 617 (33%) into the placebo group. Of the 1175 patients in the Doppler group who underwent this examination, 239 (20.3%) had abnormal uterine artery Doppler and received a prescription for aspirin. Despite the aspirin prescription, the frequency of pre-eclampsia did not differ between the systematic Doppler group and the placebo group (28 of 1237 [2.3%] vs 9 of 616 [1.5%]; RR = 1.55, 95% CI 0.7-3.3). Furthermore, the groups did not differ in the frequency of children who were very small for their gestational age (
机译：在妊娠中期，根据常规子宫动脉多普勒流速波形检查评估先兆子痫预防策略的有效性，如果发现多普勒异常，则开具100 mg阿司匹林的处方多中心随机对照试验11中心在法国北部，在比利时的一个中心.103例未怀孕的妇女在妊娠14至20周之间招募，随机化在妊娠22至24周之间接受子宫多普勒检查或接受安慰剂。多普勒波形异常的女性在36周内每天接受多普勒检查100 mg阿司匹林，先兆子痫定义为高血压（> / = 140和/或90 mmHg）与蛋白尿（> / = 0.5 g / L）相关。 253名女性（67％）被随机分为系统性多普勒组，而安慰剂组则为617名（33％）。在接受多普勒检查的1175名患者中，有239名（20.3％）子宫动脉多普勒异常并接受了阿司匹林处方。尽管有阿司匹林处方，系统性多普勒组和安慰剂组的先兆子痫发生率没有差异（1237例中的28例[2.3％] vs 616例中的9例[1.5％]; RR = 1.55，95％CI 0.7-3.3 ）。此外，这些组的胎龄（<=三分位数）或围产期死亡很小的儿童的频率没有差异。与多普勒检查结果正常的患者相比，多普勒检查结果异常的患者先兆子痫的风险较高（RR = 5.5，95％CI 2.5-12.2），并且有一个小胎龄儿（RR = 3.6） ，95％CI 1.6-8.1）。尽管对子痫前期筛查具有敏感性，但不建议未生育的孕妇在妊娠中期进行常规子宫多普勒检查。

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