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首页> 外文期刊>Anaesthesia: Journal of the Association of Anaesthetists of Great Britain and Ireland >Current options in aerosolised drug therapy for children receiving respiratory support
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Current options in aerosolised drug therapy for children receiving respiratory support

机译：用于接受呼吸支援的儿童的雾化药物治疗中的当前选择

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摘要

Inhalation of aerosolised medications are the mainstay of treatment for a number of chronic lung diseases and have several advantages over systemically-administered medications. These include more rapid onset of action for drugs such as beta-adrenergic agonists when compared with oral medication, high luminal doses for inhaled antibiotics when used to treat endobronchial infection, and an improved therapeutic index compared with systemic delivery for these and other classes of drugs such as corticosteroids. The use of aerosolised drugs to treat patients whose tracheas are intubated is less well established, in part because systemic delivery via the intravenous route can be a simpler alternative for many drugs. Consequently, research in this area is largely limited to a number of in vitro studies and very few clinical trials. Unfortunately, a lack of focus in this area has resulted in a number of practices which at best are ineffective, and at worst dangerous for the patient. Although there have been some attempts to re-invigorate research in order to improve delivery systems, current devices are, to a great extent, based on long-standing technology developed more than 50 years ago. In this review, we explore current knowledge and provide guidance as to when and how the inhaled route may be of value when treating patients whose tracheas are intubated, and we set out the challenges facing those attempting to advance the topic. We conclude by reviewing current areas of interest that may lead to more effective and widespread use of aerosols in the treatment of intubated patients.
机译：吸入雾化药物是对许多慢性肺病的治疗方法，并在全身施用的药物上具有若干优点。这些包括与口腔用药相比的药物如β-肾上腺素能激动剂等药物更快的作用，用于治疗内核感染时，吸入抗生素的高腔剂量，以及与这些和其他药物的全身递送相比，具有改善的治疗指标如皮质类固醇。使用雾化药物治疗插管的患者的内容较小，部分原因是由于通过静脉内途径的全身递送可以是许多药物的更简单的替代品。因此，该地区的研究主要限于许多体外研究和临床试验很少。不幸的是，在这一领域缺乏焦点导致了许多实践，其充其量是无效的，并且对患者最难以危险。虽然有一些尝试重新启动研究以便改善输送系统，但在很大程度上基于长期技术在50多年前发展的情况下，目前的设备在很大程度上基于。在这篇综述中，我们探索当前知识，并在治疗本发明内容的患者时，为何时以及如何以及如何以及如何以及如何在进行管道的患者中，我们列出了那些试图推进主题的人面临的挑战。我们通过审查当前的兴趣领域，这可能导致在药物患者的治疗中可能导致更有效和广泛使用气溶胶。

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