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首页> 外文期刊>Ageing Research Reviews >Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults
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Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults

机译：摩托车认知风险综合征：老年人痴呆早期痴呆症的整合

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摘要

Dementia is characterized by a long preclinical phase that may last years to decades before the onset of mild cognitive impairment. Slow gait speed and subjective memory complaint commonly co-occur during this preclinical phase, and each is a strong independent predictor of cognitive decline and dementia. Motoric cognitive risk (MCR) syndrome is a pre-dementia syndrome that combines these two early harbingers of dementia. The risk of cognitive decline or dementia is stronger for MCR than for either slow gait speed or subjective memory complaint alone. Slow gait speed and subjective memory complaint have several common risk factors: cardiovascular disease, diabetes mellitus, abnormal cortisol profiles, low vitamin D levels, brain atrophy with decreased hippocampal volume, and increased deposition of beta-amyloid in the brain. The underlying pathogenesis of MCR remains poorly understood. Metabolomics and proteomics have great potential to provide new insights into biological pathways involved in MCR during the long preclinical phase preceding dementia.
机译：痴呆症的特点是长期临床阶段，可能在轻度认知障碍前几十年到数十年。在这种临床前相位期间，缓慢的步态速度和主观记忆投诉通常是共同发生的，每个都是认知下降和痴呆的强烈独立预测因素。摩托车认知风险（MCR）综合征是一种痴呆症患者，其结合了这两个早期的痴呆症的先兆。对MCR的认知下降或痴呆症的风险比单独的缓慢步态速度或主观记忆投诉更强。缓慢的步态速度和主观记忆投诉有几种常见的风险因素：心血管疾病，糖尿病，异常的皮质醇谱，低维生素D水平，脑萎缩，海马体积降低，并增加了脑内β-淀粉样蛋白的沉积增加。 MCR的潜在发病机制仍然明显。代谢组科和蛋白质组学具有很大的潜力，可以在痴呆症期间的临床前期间参与MCR的生物途径提供新的见解。

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