...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Animal Science Journal >Effects of (-)-hydroxycitric acid on lipid droplet accumulation in chicken embryos
【24h】

Effects of (-)-hydroxycitric acid on lipid droplet accumulation in chicken embryos

机译：（ - ） - 羟基杂酸对鸡胚脂液滴积累的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n=40). After 19days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P & 0.05). Oil Red O staining analysis showed total area, counts of lipid droplets and hepatic triglyceride content were significantly decreased (P & 0.01), meanwhile hepatic lipase and lipoprotein lipase activity were significantly increased (P & 0.05). ACLY, ME1, SREBP-1c messenger RNA (mRNA) levels in 0.5-10 mg/kg groups and FAS mRNA level in 1-10 mg/kg groups were significantly decreased (P & 0.05), while PPAR mRNA level, serum adiponectin content and AdipoR1 mRNA level were significantly increased in 0.5-50 mg/kg groups (P & 0.05). These results indicated (-)-HCA treatment inhibited triglyceride synthesis via decreasing lipogenesis-related factors, mRNA expression level and accelerated lipolysis by enhancing lipoprotein lipase and hepatic lipase activity, which finally reduced lipid droplet accumulation, and this action may be associated with activating the adiponectin signaling pathway.
机译：进行该研究以确定（ - ） - 羟基羟乙酸（（ - ） - HCA）对鸡胚中的生化指标和脂质代谢参数的影响。将两百四十次受精卵分成六组，并以0,0.1,0.5,1.0,10.0和50mg / kg（n = 40）的浓度注射（ - ） - HCa。在19天孵育后，收集血清和肝脏以分析生化指数和脂质代谢参数。结果表明，血清生化指数没有显着差异：1-50mg / kg（ - ） - HCA显着增加血清葡萄糖和肝糖原含量（P＆amp; 0.05）。油红色染料分析显示出总面积，脂液滴数和肝甘油三酯含量显着降低（P＆amp; 0.01），同时肝脂肪酶和脂蛋白脂肪酶活性显着增加（P＆amp; 0.05）。在0.5-10mg / kg组和1-10mg / kg基团中的0.5-10mg / kg组和Fas mRNA水平的Me1，Srebp-1c信使RNA（mRNA）水平显着降低（P＆amp; 0.05），而PPAR mRNA水平，血清脂联素含量和Adipor1 mRNA水平在0.5-50mg / kg基团中显着增加（P＆amp; 0.05）。这些结果表明（ - ） - HCA处理通过减少脂肪生成相关因素，mRNA表达水平和加速脂解来抑制甘油三酯合成，通过增强脂蛋白脂肪酶和肝脂肪酶活性，最终降低脂质液滴积聚，并且该作用可能与激活相关联脂联素信号传导途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号