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首页> 外文期刊>Acta Poloniae Pharmaceutica: Durg Research >Assessment of cytotoxic and genotoxic activity of alcohol extract of Polyscias filicifolia shoot, leaf, cell biomass of suspension culture and saponin fraction.
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Assessment of cytotoxic and genotoxic activity of alcohol extract of Polyscias filicifolia shoot, leaf, cell biomass of suspension culture and saponin fraction.

机译：蚕丝，叶片，悬浮培养的细胞生物量和皂苷组分的乙醇提取物的细胞毒性和遗传毒性活性的评估。

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摘要

Some medicinal plants are the object of biotechnologists' special interest owing to their content of secondary metabolites, which have a strong pharmacological effect. Polyscias filicifolia is a plant known for long in traditional medicine of the Southeast Asia. Literature data suggest that it acts on the endocrine system, has adaptogenic and antiulcerative activity, shows bactericidal and insecticidal properties, restores the activity of the protein synthesis system in the conditions of long- and short-term anoxia, as well as reduces the effect of many mutagens in vitro. The purpose of the studies was to assess the cytotoxic and genotoxic effect of ethanol extracts from Polyscias filicifolia dry shoots and leaves obtained in vitro, as well as cell biomass from suspension culture. Saponin fraction from dried shoots was also tested. Initially, the cytotoxic effect was evaluated using the murine connective tissue cell line C3H/AN - L929. The genotoxic properties of the extracts were assessed using standard screening tests: the Ames test and the micronucleus test. Based on the obtained results it can be concluded that none of the extracts increases the number of revertants, both in tests with and without metabolic activation. The lack of in vitro genotoxic and mutagenic activity of tested shoot, dried leaf, cell biomass extracts, as well as the saponin fraction from dried shoots allows us to hope that Polyscias filicifolia could be used as a possible pharmaceutical raw material showing therapeutic properties.
机译：一些药用植物由于其次生代谢产物的含量而成为生物技术人员特别感兴趣的对象，其具有很强的药理作用。 Polyscias filicifolia是一种以东南亚传统医学而闻名的植物。文献资料表明，它作用于内分泌系统，具有适应性和抗溃疡活性，具有杀菌和杀虫特性，在长期和短期缺氧条件下可恢复蛋白质合成系统的活性，并降低甲氧西林的作用。体外有许多诱变剂。该研究的目的是评估体外提取的多叶锦鸡儿干芽和叶片的乙醇提取物以及悬浮培养的细胞生物量的细胞毒性和遗传毒性作用。还测试了来自干燥芽的皂苷部分。最初，使用鼠结缔组织细胞系C3H / AN-L929评估细胞毒性作用。使用标准筛选测试：Ames测试和微核测试评估提取物的遗传毒性。根据获得的结果，可以得出结论，在有或没有代谢活化的试验中，没有一种提取物会增加还原酶的数量。受试芽，干叶，细胞生物量提取物以及干芽中皂苷成分的体外遗传毒性和诱变活性不足，使我们希望将Polyscias filicifolia用作显示治疗特性的可能药物原料。

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