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首页> 外文期刊>Annual review of cell and developmental biology >The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation
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The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation

机译：FLC基因座：表观遗传学和适应中发现的平台

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Our understanding of the detailed molecular mechanisms underpinning adaptation is still poor. One example for which mechanistic understanding of regulation has converged with studies of life history variation is Arabidopsis thaliana FLOWERING LOCUS C (FLC). FLC determines the need for plants to overwinter and their ability to respond to prolonged cold in a process termed vernalization. This review highlights how molecular analysis of vernalization pathways has revealed important insight into antisense-mediated chromatin silencing mechanisms that regulate FLC. In turn, such insight has enabled molecular dissection of the diversity in vernalization across natural populations of A. thaliana. Changes in both cotranscriptional regulation and epigenetic silencing of FLC are caused by noncoding polymorphisms at FLC. The FLC locus is therefore providing important concepts for how noncoding transcription and chromatin regulation influence gene expression and how these mechanisms can vary to underpin adaptation in natural populations.
机译：我们对营养适应的详细分子机制的理解仍然很差。对法规的机械理解的一个例子融合了生命历史变异的研究是拟南芥开花基因座C（FLC）。 FLC决定了植物的需求溢冬，并且它们在春化的过程中延长感冒的能力。该综述突出了春化途径的分子分析如何揭示了对调节FLC的反义介导的染色质沉默机制的重要见解。反过来，这种洞察力使跨A.蒂利亚纳天然群体的春化的多样性的分子解剖。 FLC的COTRANSCRAPE调节和表观遗传沉默的变化是由FLC的非编码多态性引起的。因此，FLC基因座是为非编码转录和染色质调节如何影响基因表达以及这些机制如何变化在天然群体中的适应性方面的重要概念。

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