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Cytoplasmic Intermediate Filaments in Cell Biology

机译:细胞生物学中的细胞质中间细丝

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摘要

Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their stability, intrinsic mechanical properties, and cell type-specific expression patterns distinguish them from actin and microtubules. By providing mechanical support, IFs protect cells from external forces and participate in cell adhesion and tissue integrity. IFs form an extensive and elaborate network that connects the cell cortex to intracellular organelles. They act as a molecular scaffold that controls intracellular organization. However, IFs have been revealed as much more than just rigid structures. Their dynamics is regulated by multiple signaling cascades and appears to contribute to signaling events in response to cell stress and to dynamic cellular functions such as mitosis, apoptosis, and migration.
机译:中间细丝(IFS)是细胞骨架的三个主要元素之一。 它们的稳定性,内在力学性能和细胞类型特异性表达模式将它们与肌动蛋白和微管区分开。 通过提供机械支撑,IFS保护来自外力的细胞并参与细胞粘附和组织完整性。 ifs形成一个广泛和精细的网络,将细胞皮质连接到细胞内细胞器。 它们作为控制细胞内组织的分子支架。 但是,如果已被揭示不仅仅是刚性结构。 它们的动态由多个信号级联调节,并且似乎有助于响应于细胞应激和动态蜂窝功能,例如有丝分裂,细胞凋亡和迁移的动态蜂窝功能。

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