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首页> 外文期刊>Annual review of cell and developmental biology >Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids
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Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids

机译：微生物核酸的识别和防御细胞质机制

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摘要

Microbial nucleic acids are major signatures of invading pathogens, and their recognition by various host pattern recognition receptors (PRRs) represents the first step toward an efficient innate immune response to clear the pathogens. The nucleic acid-sensing PRRs are localized at the plasma membrane, the cytosol, and/or various cellular organelles. Sensing of nucleic acids and signaling by PRRs involve recruitment of distinct signaling components, and PRRs are intensively regulated by cellular organelle trafficking. PRR-mediated innate immune responses are also heavily regulated by post-translational modifications, including phosphorylation, polyubiquitination, sumoylation, and glutamylation. In this review, we focus on our current understanding of recognition of microbial nucleic acid by PRRs, particularly on their regulation by organelle trafficking and posttranslational modifications. We also discuss how sensing of self nucleic acids and dysregulation of PRR-mediated signaling lead to serious human diseases.
机译：微生物核酸是侵入病原体的主要特征，其各种宿主模式识别受体（PRRS）的识别代表了朝着清除病原体的有效先天免疫应答的第一步。核酸感测PRR在质膜，胞浆和/或各种细胞细胞内部定位。 PRRS的核酸和信号传导的感应涉及招募不同的信号传导组分，并且PRRS通过细胞细胞器贩运强烈调节。 PRR介导的先天免疫应答也是通过翻译后修饰的严重调节，包括磷酸化，多聚泛素，平等和谷氨酸。在这篇综述中，我们专注于我们目前对PRRS识别微生物核酸的认识，特别是在细胞器贩运和后期修改的监管。我们还讨论了如何对自我核酸和PRR介导的信号传导的失衡感测到严重的人类疾病。

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