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首页> 外文期刊>Annual review of cell and developmental biology >Mucins and Their Role in Shaping the Functions of Mucus Barriers
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Mucins and Their Role in Shaping the Functions of Mucus Barriers

机译：粘蛋白及其在塑造粘液屏障的功能方面的作用

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摘要

We review what is currently understood about how the structure of the primary solid component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical properties of mucus that are required for it to perform its diverse physiological roles. Macroscale processes such as lubrication require mucus of a certain stiffness and spinnability, which are set by structural features of the mucin network, including the identity and density of cross-links and the degree of glycosylation. At the microscale, these same features affect the mechanical environment experienced by small particles and play a crucial role in establishing an interaction-based filter. Finally, mucin glycans are critical for regulating microbial interactions, serving as receptor binding sites for adhesion, as nutrient sources, and as environmental signals. We conclude by discussing how these structural principles can be used in the design of synthetic mucin-mimetic materials and provide suggestions for directions of future work in this field.
机译：我们审查目前了解关于粘液原发性固体组分的结构，糖蛋白粘蛋白粘蛋白粘蛋白的结构如何产生粘液所需的机械和生化特性，以进行其不同的生理作用。诸如润滑之类的宏观方法需要一定的刚度和可旋转性的粘液，其由粘蛋白网络的结构特征设定，包括交联和糖基化程度的身份和密度。在微尺寸，这些相同的功能影响小颗粒经历的机械环境，并在建立基于相互作用的滤波器方面发挥至关重要的作用。最后，粘蛋白聚糖对于调节微生物相互作用至关重要，该微生物相互作用是用于粘附的受体结合位点，作为营养源，作为环境信号。我们通过讨论这些结构原理如何在合成粘蛋白 - 模拟材料设计中使用的结论，并为该领域的未来工作方向提供建议。

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