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Symmetry Breaking in the Mammalian Embryo

机译:在哺乳动物胚胎中打破对称性

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We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development. Although we primarily discuss embryonic development of the mouse, as it is the best-studied mammalian model system to date, we also highlight the shared and distinct aspects between different mammalian species. Finally, we discuss how insights gained from studying mammalian development can be generalized in light of self-organization principles. With this review, we hope to highlight new perspectives in studying symmetry breaking and self-organization in multicellular systems.
机译:我们概述了早期哺乳动物开发中的对称性破碎,作为从压实到身体轴的规格的连续过程。 虽然早期的研究专注于个人对称事件,但最近的进步使我们能够在早期哺乳动物发展期间探讨逐步的对称性。 虽然我们主要讨论鼠标的胚胎发育,但它是迄今为止最好的哺乳动物模型系统,我们还突出了不同哺乳动物物种之间的共同和独特方面。 最后,我们讨论如何从学习哺乳动物发展中获得的洞察力可以通过自组织原则来推广。 有了这篇综述,我们希望能够突出新的观点来研究多细胞系统中的对称性突破和自组织。

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