• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual review of cell and developmental biology >Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications
【24h】

Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications

机译：内外弯曲细胞：酒吧域蛋白在膜整形中的作用及其细胞意义

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many cellular processes rely on precise and timely deformation of the cell membrane.While many proteins participate in membrane reshaping and scission, usually in highly specialized ways, Bin/amphiphysin/Rvs (BAR) domain proteins play a pervasive role, as they not only participate in many aspects of cell trafficking but also are highly versatile membrane remodelers.Subtle changes in the shape and size of the BAR domain can greatly impact the way in which BAR domain proteins interact with the membrane.Furthermore, the activity of BAR domain proteins can be tuned by external physical parameters, and so they behave differently depending on protein surface density, membrane tension, or membrane shape.These proteins can form 3D structures that mold the membrane and alter its liquid properties, even promoting scission under various circumstances.As such, BAR domain proteins have numerous roles within the cell.Endocytosis is among the most highly studied processes in which BAR domain proteins take on important roles.Over the years, a more complete picture has emerged in which BAR domain proteins are tied to almost all intracellular compartments; examples include endosomal sorting and tubular networks in the endoplasmic reticulum and T-tubules.These proteins also have a role in autophagy, and their activity has been linked with cancer.Here, we briefly review the history of BAR domain protein discovery, discuss the mechanisms by which BAR domain proteins induce curvature, and attempt to settle important controversies in the field.Finally, we review BAR domain proteins in the context of a cell, highlighting their emerging roles in cell signaling and organelle shaping.
机译：许多细胞工艺依赖于细胞膜的精确和及时变形。当许多蛋白质参与膜重塑和裂变，通常以高度专业化的方式，箱/ amphiphysin / RVS（Bar）域蛋白发挥普遍的作用，因为它们不仅参与在细胞贩运的许多方面，但也是高度通用的膜改造。酒吧结构域的形状和尺寸的变化可以大大影响栏杆域蛋白与膜相互作用的方式。诸如此，可以是杆状域蛋白的活性由外部物理参数调节，因此它们取决于蛋白质表面密度，膜张力或膜形状不同。这些蛋白质可以形成模塑膜的3D结构并改变其液体性质，甚至在各个情况下促进群体。那样，酒吧域蛋白质在细胞内具有许多作用。吞噬作用是最高度研究的方法中，其中栏杆蛋白承担重要作用。多年来，已经出现了更完整的图景，其中栏域蛋白质与几乎所有的细胞内隔室相关联;实例包括在内质网和T-cubles中的内体分选和管状网络。这些蛋白质也具有自噬作用，它们的活性与癌症有关。我们简要介绍了酒吧域蛋白发现的历史，讨论了机制通过哪个酒吧域蛋白诱导曲率，并试图在现场进行重要争议。最后，我们在细胞的背景下审查酒吧域蛋白，突出了它们在细胞信号传导和细胞器整形中的新兴作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号