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首页> 外文期刊>Annals of epidemiology >The prevalence of obesity is increased in patients with late compared with early onset psoriasis
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The prevalence of obesity is increased in patients with late compared with early onset psoriasis

机译：与早期发作牛皮癣相比，患者患者的肥胖患病率增加

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摘要

Purpose: We compared the clinical and epidemiologic characteristics of early and late onset psoriasis with an emphasis on potential differences in the comorbidities associated with each subtype. Methods: An observational, multicenter study was performed, and associations between the age at the time of diagnosis and binary comorbidity outcomes were evaluated using multiple logistic regression analysis adjusted for age and other relevant confounders. Results: An increased prevalence of positive family history, psoriatic arthritis, and depression was observed in patients with early onset psoriasis. On the other hand, late onset psoriasis was more frequently associated with obesity and elevated waist circumference compared with early onset form. Elderly psoriatic patients (at the age of 75 years) with late onset psoriasis are at an especially high risk for obesity compared with individuals at the same age with an early onset disease. Conclusions: The increased frequency of psoriasis in the family of early onset patients may suggest that manifestation of psoriasis at younger age is driven by strong genetic influence. However, such a remarkable association of abdominal obesity with late onset psoriasis may suggest that obesity can be one of the acquired factors that may predispose for the development of psoriasis in the elderly.
机译：目的：我们比较了早期和后期发作牛皮癣的临床和流行病学特征，重点是与每种亚型相关的合并症的潜在差异。方法：进行观察，多中心研究，使用多元逻辑回归分析评估诊断时间和二元合并症的年龄之间的关联，调整为年龄和其他相关混杂。结果：患有早期发作牛皮癣的患者中，观察到阳性家族史，银屑病关节炎和抑郁症的患病率增加。另一方面，与早期发作形式相比，晚期发作牛皮癣更频繁地与肥胖症​​和升高的腰围相关。老年银屑病患者（75岁岁月），后期发病牛皮癣是肥胖的特别高的风险，与同龄人的患者与早期发病疾病相比。结论：早期发病患者家庭牛皮癣频率增加可能表明，幼龄年龄的牛皮癣的表现因强烈的遗传影响而导致。然而，具有晚期发作牛皮癣的如此显着的腹部肥胖协会可能表明肥胖可以是所获得的因素之一，可以促使老年人牛皮癣的发展。

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  • 来源
    《Annals of epidemiology》 |2013年第11期|共5页
  • 作者

    HerédiE.; CsordásA.; ClemensM.; ádámB.; GáspárK.; T?rocsikD.; NagyG.; ádányR.; GaálJ.; Remenyiké.; SzegediA.;

  • 作者单位

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Cardiology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Preventive Medicine Medical and Health Science Centre University of Debrecen;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Preventive Medicine Medical and Health Science Centre University of Debrecen;

    Department of Rheumatology Kenézy Gyula Hospital Debrecen Hungary;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

    Department of Dermatology Medical and Health Science Centre University of Debrecen Hungary;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 流行病学与防疫;
  • 关键词

    Age of onset; Comorbidity; Psoriasis;

    机译：发病年龄;合并症;牛皮癣;

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