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首页> 外文期刊>Annals of epidemiology >The prevalence of obesity is increased in patients with late compared with early onset psoriasis
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The prevalence of obesity is increased in patients with late compared with early onset psoriasis

机译：与早期发作的牛皮癣相比，晚期患者的肥胖发生率增加

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Purpose: We compared the clinical and epidemiologic characteristics of early and late onset psoriasis with an emphasis on potential differences in the comorbidities associated with each subtype. Methods: An observational, multicenter study was performed, and associations between the age at the time of diagnosis and binary comorbidity outcomes were evaluated using multiple logistic regression analysis adjusted for age and other relevant confounders. Results: An increased prevalence of positive family history, psoriatic arthritis, and depression was observed in patients with early onset psoriasis. On the other hand, late onset psoriasis was more frequently associated with obesity and elevated waist circumference compared with early onset form. Elderly psoriatic patients (at the age of 75 years) with late onset psoriasis are at an especially high risk for obesity compared with individuals at the same age with an early onset disease. Conclusions: The increased frequency of psoriasis in the family of early onset patients may suggest that manifestation of psoriasis at younger age is driven by strong genetic influence. However, such a remarkable association of abdominal obesity with late onset psoriasis may suggest that obesity can be one of the acquired factors that may predispose for the development of psoriasis in the elderly.
机译：目的：我们比较了早期和晚期银屑病的临床和流行病学特征，重点是与每种亚型相关的合并症的潜在差异。方法：进行了一项观察性，多中心研究，并使用针对年龄和其他相关混杂因素进行调整的多元逻辑回归分析，评估了诊断时的年龄与二元合并症结局之间的关联。结果：早发性牛皮癣患者的阳性家族史，银屑病关节炎和抑郁症患病率增加。另一方面，与早发型相比，晚发型牛皮癣更常见于肥胖和腰围升高。与同年龄的早发性疾病患者相比，晚期银屑病的老年银屑病患者（75岁）肥胖的风险特别高。结论：早发患者家族中牛皮癣的发病率增加可能表明，年轻的牛皮癣表现是受强大的遗传影响所驱动的。然而，腹部肥胖与晚期银屑病的这种显着联系可能表明，肥胖可能是可能导致老年人牛皮癣发展的后天因素之一。

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